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- W2024210411 abstract "<i>Objectives:</i> This retrospective study was undertaken to analyze the profile of patients presenting with renal cell carcinoma (RCC) and treatment outcomes. <i>Subjects and Methods:</i> Records of 49 patients (36 male, 16 female, 21–75 years) treated at the Kuwait Cancer Control Center, Kuwait for RCC during the period 1993–1998 were analyzed. Forty-one patients had a nephrectomy, 18 postoperative radiotherapy and 1 patient also received adjuvant immunotherapy with interferon. Patients with metastatic disease were treated with a variety of agents including interferon, chemotherapy (vinblastine) or a hormonal agent (megestrol acetate). Data analysis was performed using SPSS statistical software package. Overall survival and disease-free survival were calculated using the Kaplan-Meier method. <i>Results:</i> Twenty-nine patients presented with symptoms classically associated with RCC. Metastases at diagnosis were seen in 9 patients (18%), with lung being the most frequent site. The commonest tumor subtype was clear cell carcinoma (32.6%). Thirty-nine patients (80%) achieved a complete response to treatment and relapse was documented in 10 patients (26%). The majority of failures were distant, with lung metastases being the most common. Response to salvage treatment was poor. Overall survival was 83% at 2 years. The disease-free survival was 68 and 45% at 2 and 5 years, respectively. <i>Conclusions:</i> Although many patients presented with advanced local disease, a majority achieved complete response after radical surgery with or without postoperative radiation therapy. Salvage of metastatic disease proved difficult with interferon, chemotherapy." @default.
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- W2024210411 date "2004-12-15" @default.
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- W2024210411 title "Renal Cell Carcinoma: The Experience of Kuwait Cancer Control Center, Kuwait" @default.
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- W2024210411 doi "https://doi.org/10.1159/000081914" @default.
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