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• W2024211037 abstract "RNA-directed DNA methylation (RdDM) involves sequence-specific guiding of the de novo methylation machinery to complementary genomic DNA by RNA molecules. It is still elusive whether guide RNAs bind directly to DNA or to nascent transcripts produced from it. Even the nature of the guide RNAs is not elucidated. RNA interference (RNAi) studies provided a link between RNAi and RdDM indicating that small interfering RNAs (siRNAs) trigger and guide cytosine methylation. The “siRNA hypothesis” is generally accepted. However, recent data demonstrated that RdDM is not always associated with the accumulation of corresponding siRNAs. RdDM triggers may differ from guide RNAs and further studies are needed to clarify if guide RNAs are small or long RNAs, if they are single or double stranded and if they target DNA or nascent transcript." @default.
• W2024211037 created "2016-06-24" @default.
• W2024211037 creator A5059103410 @default.
• W2024211037 creator A5066807390 @default.
• W2024211037 date "2013-03-01" @default.
• W2024211037 modified "2023-10-11" @default.
• W2024211037 title "Revisiting RNA-directed DNA methylation" @default.
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• W2024211037 doi "https://doi.org/10.4161/rna.23542" @default.
• W2024211037 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3672289" @default.
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