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- W2024223820 abstract "Ultraviolet (UV) radiation is one of the important cataract risk factors. However, the pathogenesis is still poorly understood. The migration of human lens epithelial cells(HLECs) plays a crucial role in the remodeling of lens capsule and cataract formation. The purpose of this study is to investigate the mechanism of UV inducing cataractogenesis. The toxicity of UV-irradiation on HLECs was assessed by Methyl thiazolyl tetrazolium(MTT) assay. The activity of matrix metalloproteinase-2(MMP-2) was observed by Gelatin zymography. The migration of HLECs was examined by Cell Track Motility. UV-irradiation does great harm to HLECs, and may induce apoptosis in the cells when UV higher than 15 mj/cm2. UV significantly increased MMP-2 activity in a time-dependent manner. In addition, the irradiation could induce the migration of HLECs. UV-irradiation could induce the migration of HLECs by increasing the activity of MMP-2." @default.
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- W2024223820 date "2008-05-01" @default.
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- W2024223820 title "The migration of human lens epithelial cells induced by UV-irradiation in vitro" @default.
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- W2024223820 doi "https://doi.org/10.1016/s1007-4376(08)60053-2" @default.
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