Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024224022> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2024224022 endingPage "163" @default.
- W2024224022 startingPage "159" @default.
- W2024224022 abstract "We have previously demonstrated that subclinical chronic rejection (CR) induces structural and functional alterations in enteric smooth muscle and nerves in a rat model of small intestinal transplantation. This study was designed to investigate the effect of prolonged FK506 rescue therapy on these sequelae of CR. Immunohistochemistry of BrdU-labeled muscle cells demonstrated that active proliferation of intestinal smooth muscle caused by CR was successfully aborted by FK506 rescue therapy after a period of 30 days (control = 0.14 +/- 0.09; CR = 30.4 +/- 1.73; rescue = 2.4 +/- 0.63 cells/jejunal cross-section, P < 0.01). However, FK506 did not reverse the already established increase in muscular thickness (control = 92 +/- 2.4; CR = 193 +/- 10.6; rescue = 188 +/- 8.1 microns) due to CR. Bethanechol stimulated circular muscle contractility was improved markedly with rescue therapy (maximal contractile force reached 39.5% of control values in CR grafts and 68.8% after rescue). Rescue therapy did not reverse the loss of NADPH-diaphorase positive myenteric ganglia (control = 37 +/- 1.4; CR = 28 +/- 2.9; rescue = 23 +/- 1.7 ganglia/cross-section). Despite the persistent loss of ganglia, inhibitory junction potentials (IJPs) improved significantly returning to control values with FK506 (control = 10 +/- 0.5; CR = 5 +/- 0.3; CR rescue = 10 +/- 0.7 mV; IJPs recorded at 1 pulse/150V/0.75 ms). Although structural changes in enteric smooth muscle and myenteric neurons induced by CR were not reversed, the progression of subclinical CR can be effectively curbed by FK506 rescue therapy. The improvement in muscular mechanics and inhibitory neural innervation is probably due to the cessation of infiltrating immunocytes and sprouting of remaining myenteric nerves." @default.
- W2024224022 created "2016-06-24" @default.
- W2024224022 creator A5007344779 @default.
- W2024224022 creator A5014007420 @default.
- W2024224022 creator A5026096785 @default.
- W2024224022 creator A5042965869 @default.
- W2024224022 creator A5059189391 @default.
- W2024224022 date "1995-01-01" @default.
- W2024224022 modified "2023-09-25" @default.
- W2024224022 title "Functional Impairment Of Enteric Smooth Muscle And Nerves Caused By Chronic Intestinal Allograft Rejection Regresses After Fk506 Rescue" @default.
- W2024224022 doi "https://doi.org/10.1097/00007890-199501000-00001" @default.
- W2024224022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7530870" @default.
- W2024224022 hasPublicationYear "1995" @default.
- W2024224022 type Work @default.
- W2024224022 sameAs 2024224022 @default.
- W2024224022 citedByCount "28" @default.
- W2024224022 countsByYear W20242240222018 @default.
- W2024224022 crossrefType "journal-article" @default.
- W2024224022 hasAuthorship W2024224022A5007344779 @default.
- W2024224022 hasAuthorship W2024224022A5014007420 @default.
- W2024224022 hasAuthorship W2024224022A5026096785 @default.
- W2024224022 hasAuthorship W2024224022A5042965869 @default.
- W2024224022 hasAuthorship W2024224022A5059189391 @default.
- W2024224022 hasConcept C105702510 @default.
- W2024224022 hasConcept C113280763 @default.
- W2024224022 hasConcept C126322002 @default.
- W2024224022 hasConcept C134018914 @default.
- W2024224022 hasConcept C170493617 @default.
- W2024224022 hasConcept C2777439022 @default.
- W2024224022 hasConcept C2780660124 @default.
- W2024224022 hasConcept C2911091166 @default.
- W2024224022 hasConcept C33789571 @default.
- W2024224022 hasConcept C39133596 @default.
- W2024224022 hasConcept C71924100 @default.
- W2024224022 hasConcept C86803240 @default.
- W2024224022 hasConceptScore W2024224022C105702510 @default.
- W2024224022 hasConceptScore W2024224022C113280763 @default.
- W2024224022 hasConceptScore W2024224022C126322002 @default.
- W2024224022 hasConceptScore W2024224022C134018914 @default.
- W2024224022 hasConceptScore W2024224022C170493617 @default.
- W2024224022 hasConceptScore W2024224022C2777439022 @default.
- W2024224022 hasConceptScore W2024224022C2780660124 @default.
- W2024224022 hasConceptScore W2024224022C2911091166 @default.
- W2024224022 hasConceptScore W2024224022C33789571 @default.
- W2024224022 hasConceptScore W2024224022C39133596 @default.
- W2024224022 hasConceptScore W2024224022C71924100 @default.
- W2024224022 hasConceptScore W2024224022C86803240 @default.
- W2024224022 hasIssue "2" @default.
- W2024224022 hasLocation W20242240221 @default.
- W2024224022 hasLocation W20242240222 @default.
- W2024224022 hasOpenAccess W2024224022 @default.
- W2024224022 hasPrimaryLocation W20242240221 @default.
- W2024224022 hasRelatedWork W1514902666 @default.
- W2024224022 hasRelatedWork W1964891915 @default.
- W2024224022 hasRelatedWork W2012347043 @default.
- W2024224022 hasRelatedWork W2076401226 @default.
- W2024224022 hasRelatedWork W2077755216 @default.
- W2024224022 hasRelatedWork W2083952118 @default.
- W2024224022 hasRelatedWork W2084505320 @default.
- W2024224022 hasRelatedWork W2088891312 @default.
- W2024224022 hasRelatedWork W2114671826 @default.
- W2024224022 hasRelatedWork W2462138745 @default.
- W2024224022 hasVolume "59" @default.
- W2024224022 isParatext "false" @default.
- W2024224022 isRetracted "false" @default.
- W2024224022 magId "2024224022" @default.
- W2024224022 workType "article" @default.