FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024227162> ?p ?o ?g. }

• W2024227162 endingPage "2585" @default.
• W2024227162 startingPage "2575" @default.
• W2024227162 abstract "Allostery in the binding of peptides to DNA has been studied by quantitative DNase I footprinting using four newly designed peptides containing the XP(Hyp)RK motif and N-methylpyrrole (Py) moieties. Apparent binding constants in the micromolar range as well as Hill coefficients were determined for each peptide. The results, together with previous studies on five other peptides support the proposal that interaction network cooperativity is highly preferred in DNA–peptide interactions that involve multiple recognition sites. It is envisaged that interstrand bidentate interactions participate in the relay of conformational changes between recognition sites on the complementary strands. Models for interpreting DNA allostery based upon interaction networks are outlined. Circular dichroism experiments involving the titration of peptides against a short oligonucleotide duplex indicate that some of these peptides bind in a dimeric manner to DNA via the minor groove, inducing characteristic conformational changes. These insights should prompt the design of new DNA-binding peptides for investigating allosteric interactions between peptides and DNA, as well as novel interaction networks, and ultimately may shed light upon the fundamental chemical rules that govern allostery in more complex biological process such as DNA–protein interaction networks." @default.
• W2024227162 created "2016-06-24" @default.
• W2024227162 creator A5007934664 @default.
• W2024227162 creator A5024450667 @default.
• W2024227162 creator A5034235724 @default.
• W2024227162 creator A5043040190 @default.
• W2024227162 creator A5049547042 @default.
• W2024227162 creator A5050472878 @default.
• W2024227162 creator A5057275089 @default.
• W2024227162 creator A5058307216 @default.
• W2024227162 creator A5058383885 @default.
• W2024227162 creator A5063837282 @default.
• W2024227162 creator A5068519560 @default.
• W2024227162 creator A5068739746 @default.
• W2024227162 date "2010-04-01" @default.
• W2024227162 modified "2023-10-18" @default.
• W2024227162 title "Novel DNA–peptide interaction networks" @default.
• W2024227162 cites W1545558475 @default.
• W2024227162 cites W1970704831 @default.
• W2024227162 cites W1976180993 @default.
• W2024227162 cites W1983962122 @default.
• W2024227162 cites W1987881945 @default.
• W2024227162 cites W2008475801 @default.
• W2024227162 cites W2010022403 @default.
• W2024227162 cites W2042267577 @default.
• W2024227162 cites W2043691497 @default.
• W2024227162 cites W2054718271 @default.
• W2024227162 cites W2057815053 @default.
• W2024227162 cites W2064159624 @default.
• W2024227162 cites W2064971479 @default.
• W2024227162 cites W2071669933 @default.
• W2024227162 cites W2095057498 @default.
• W2024227162 cites W2095175905 @default.
• W2024227162 cites W2114313066 @default.
• W2024227162 cites W2125714273 @default.
• W2024227162 cites W2137154596 @default.
• W2024227162 cites W2164928285 @default.
• W2024227162 cites W34532530 @default.
• W2024227162 cites W4249294056 @default.
• W2024227162 doi "https://doi.org/10.1016/j.bmc.2010.02.047" @default.
• W2024227162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20338768" @default.
• W2024227162 hasPublicationYear "2010" @default.
• W2024227162 type Work @default.
• W2024227162 sameAs 2024227162 @default.
• W2024227162 citedByCount "5" @default.
• W2024227162 countsByYear W20242271622013 @default.
• W2024227162 countsByYear W20242271622014 @default.
• W2024227162 countsByYear W20242271622018 @default.
• W2024227162 crossrefType "journal-article" @default.
• W2024227162 hasAuthorship W2024227162A5007934664 @default.
• W2024227162 hasAuthorship W2024227162A5024450667 @default.
• W2024227162 hasAuthorship W2024227162A5034235724 @default.
• W2024227162 hasAuthorship W2024227162A5043040190 @default.
• W2024227162 hasAuthorship W2024227162A5049547042 @default.
• W2024227162 hasAuthorship W2024227162A5050472878 @default.
• W2024227162 hasAuthorship W2024227162A5057275089 @default.
• W2024227162 hasAuthorship W2024227162A5058307216 @default.
• W2024227162 hasAuthorship W2024227162A5058383885 @default.
• W2024227162 hasAuthorship W2024227162A5063837282 @default.
• W2024227162 hasAuthorship W2024227162A5068519560 @default.
• W2024227162 hasAuthorship W2024227162A5068739746 @default.
• W2024227162 hasConcept C107824862 @default.
• W2024227162 hasConcept C12554922 @default.
• W2024227162 hasConcept C129312508 @default.
• W2024227162 hasConcept C133571119 @default.
• W2024227162 hasConcept C166014724 @default.
• W2024227162 hasConcept C166342909 @default.
• W2024227162 hasConcept C181199279 @default.
• W2024227162 hasConcept C185592680 @default.
• W2024227162 hasConcept C187250156 @default.
• W2024227162 hasConcept C2778021871 @default.
• W2024227162 hasConcept C2779281246 @default.
• W2024227162 hasConcept C3017666073 @default.
• W2024227162 hasConcept C552990157 @default.
• W2024227162 hasConcept C55493867 @default.
• W2024227162 hasConcept C61234307 @default.
• W2024227162 hasConcept C71240020 @default.
• W2024227162 hasConcept C86803240 @default.
• W2024227162 hasConceptScore W2024227162C107824862 @default.
• W2024227162 hasConceptScore W2024227162C12554922 @default.
• W2024227162 hasConceptScore W2024227162C129312508 @default.
• W2024227162 hasConceptScore W2024227162C133571119 @default.
• W2024227162 hasConceptScore W2024227162C166014724 @default.
• W2024227162 hasConceptScore W2024227162C166342909 @default.
• W2024227162 hasConceptScore W2024227162C181199279 @default.
• W2024227162 hasConceptScore W2024227162C185592680 @default.
• W2024227162 hasConceptScore W2024227162C187250156 @default.
• W2024227162 hasConceptScore W2024227162C2778021871 @default.
• W2024227162 hasConceptScore W2024227162C2779281246 @default.
• W2024227162 hasConceptScore W2024227162C3017666073 @default.
• W2024227162 hasConceptScore W2024227162C552990157 @default.
• W2024227162 hasConceptScore W2024227162C55493867 @default.
• W2024227162 hasConceptScore W2024227162C61234307 @default.
• W2024227162 hasConceptScore W2024227162C71240020 @default.
• W2024227162 hasConceptScore W2024227162C86803240 @default.
• W2024227162 hasIssue "7" @default.
• W2024227162 hasLocation W20242271621 @default.
• W2024227162 hasLocation W20242271622 @default.

• next