Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024231721> ?p ?o ?g. }
- W2024231721 endingPage "144" @default.
- W2024231721 startingPage "138" @default.
- W2024231721 abstract "Inducible regulatory T-cells (iTReg) can be generated from CD4+Foxp3− naïve conventional T-cells by a combination of TGF-β and T-cell receptor (TCR) signaling. It is of enormous clinical importance to identify agents that can promote the generation and differentiation of functional iTreg cells. We have established a phenotypic screening platform to identify new compounds that can promote the TGFβ-mediated iTreg differentiation. We have found Kenpaullone, a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation. Kenpaullone promotes iTreg cell differentiation through increased and prolonged transcription of foxp3 gene by enhancing TGFβ-Smad3 signaling pathway. Thus, we have demonstrated that CDK2 is the biological target of Kenpaullone and proven that CDK2 is a novel negative regulator of iTreg cell differentiation." @default.
- W2024231721 created "2016-06-24" @default.
- W2024231721 creator A5007108734 @default.
- W2024231721 creator A5037390684 @default.
- W2024231721 creator A5041545335 @default.
- W2024231721 creator A5043524433 @default.
- W2024231721 creator A5087012625 @default.
- W2024231721 date "2014-07-01" @default.
- W2024231721 modified "2023-10-07" @default.
- W2024231721 title "Inhibition of CDK2 promotes inducible regulatory T-cell differentiation through TGFβ-Smad3 signaling pathway" @default.
- W2024231721 cites W1611284225 @default.
- W2024231721 cites W1915822097 @default.
- W2024231721 cites W1979982823 @default.
- W2024231721 cites W1980069352 @default.
- W2024231721 cites W1999319877 @default.
- W2024231721 cites W2002726823 @default.
- W2024231721 cites W2009343059 @default.
- W2024231721 cites W2019077533 @default.
- W2024231721 cites W2021603971 @default.
- W2024231721 cites W2038127753 @default.
- W2024231721 cites W2049518790 @default.
- W2024231721 cites W2101475722 @default.
- W2024231721 cites W2102792272 @default.
- W2024231721 cites W2106030214 @default.
- W2024231721 cites W2117970385 @default.
- W2024231721 cites W2120010406 @default.
- W2024231721 cites W2122591224 @default.
- W2024231721 cites W2126072190 @default.
- W2024231721 cites W2128211931 @default.
- W2024231721 cites W2142263069 @default.
- W2024231721 cites W2145353379 @default.
- W2024231721 cites W2152642587 @default.
- W2024231721 cites W2157307300 @default.
- W2024231721 cites W2162704072 @default.
- W2024231721 cites W2169233545 @default.
- W2024231721 doi "https://doi.org/10.1016/j.cellimm.2014.05.004" @default.
- W2024231721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24978614" @default.
- W2024231721 hasPublicationYear "2014" @default.
- W2024231721 type Work @default.
- W2024231721 sameAs 2024231721 @default.
- W2024231721 citedByCount "12" @default.
- W2024231721 countsByYear W20242317212015 @default.
- W2024231721 countsByYear W20242317212016 @default.
- W2024231721 countsByYear W20242317212017 @default.
- W2024231721 countsByYear W20242317212018 @default.
- W2024231721 countsByYear W20242317212019 @default.
- W2024231721 countsByYear W20242317212020 @default.
- W2024231721 countsByYear W20242317212022 @default.
- W2024231721 crossrefType "journal-article" @default.
- W2024231721 hasAuthorship W2024231721A5007108734 @default.
- W2024231721 hasAuthorship W2024231721A5037390684 @default.
- W2024231721 hasAuthorship W2024231721A5041545335 @default.
- W2024231721 hasAuthorship W2024231721A5043524433 @default.
- W2024231721 hasAuthorship W2024231721A5087012625 @default.
- W2024231721 hasConcept C104317684 @default.
- W2024231721 hasConcept C111936080 @default.
- W2024231721 hasConcept C118131993 @default.
- W2024231721 hasConcept C120504264 @default.
- W2024231721 hasConcept C148738053 @default.
- W2024231721 hasConcept C1491633281 @default.
- W2024231721 hasConcept C184235292 @default.
- W2024231721 hasConcept C203014093 @default.
- W2024231721 hasConcept C2778229498 @default.
- W2024231721 hasConcept C2779727006 @default.
- W2024231721 hasConcept C29537977 @default.
- W2024231721 hasConcept C54355233 @default.
- W2024231721 hasConcept C62478195 @default.
- W2024231721 hasConcept C6929976 @default.
- W2024231721 hasConcept C82495950 @default.
- W2024231721 hasConcept C86339819 @default.
- W2024231721 hasConcept C86803240 @default.
- W2024231721 hasConcept C8891405 @default.
- W2024231721 hasConcept C95444343 @default.
- W2024231721 hasConcept C97029542 @default.
- W2024231721 hasConceptScore W2024231721C104317684 @default.
- W2024231721 hasConceptScore W2024231721C111936080 @default.
- W2024231721 hasConceptScore W2024231721C118131993 @default.
- W2024231721 hasConceptScore W2024231721C120504264 @default.
- W2024231721 hasConceptScore W2024231721C148738053 @default.
- W2024231721 hasConceptScore W2024231721C1491633281 @default.
- W2024231721 hasConceptScore W2024231721C184235292 @default.
- W2024231721 hasConceptScore W2024231721C203014093 @default.
- W2024231721 hasConceptScore W2024231721C2778229498 @default.
- W2024231721 hasConceptScore W2024231721C2779727006 @default.
- W2024231721 hasConceptScore W2024231721C29537977 @default.
- W2024231721 hasConceptScore W2024231721C54355233 @default.
- W2024231721 hasConceptScore W2024231721C62478195 @default.
- W2024231721 hasConceptScore W2024231721C6929976 @default.
- W2024231721 hasConceptScore W2024231721C82495950 @default.
- W2024231721 hasConceptScore W2024231721C86339819 @default.
- W2024231721 hasConceptScore W2024231721C86803240 @default.
- W2024231721 hasConceptScore W2024231721C8891405 @default.
- W2024231721 hasConceptScore W2024231721C95444343 @default.
- W2024231721 hasConceptScore W2024231721C97029542 @default.
- W2024231721 hasIssue "1" @default.
- W2024231721 hasLocation W20242317211 @default.
- W2024231721 hasLocation W20242317212 @default.
- W2024231721 hasOpenAccess W2024231721 @default.