FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024234239> ?p ?o ?g. }

• W2024234239 endingPage "19957" @default.
• W2024234239 startingPage "19952" @default.
• W2024234239 abstract "Cord blood (CB) hematopoietic stem cell transplantation can be successful even if donor and recipient are not fully matched for human leukocyte antigens (HLA). This may result from tolerance-inducing events during pregnancy but to date this concept has not been tested in CB transplantation. Hence we analyzed the impact of fetal exposure to noninherited maternal antigens (NIMA) of the HLA-A, -B antigens, or -DRB1 alleles on the outcome of CB transplants. The 1,121 patients studied were transplanted for hematological malignancy with a single CB unit: 1,059 received grafts mismatched for one or two HLA antigens. Of these patients, 79 patients had a mismatched antigen that was identical to a donor NIMA, 25 with one HLA mismatch (MM), and 54 with two. If there was a NIMA match, transplant-related mortality (TRM) was improved, especially in patients >or=10 years (P = 0.012) as were overall mortality and treatment failure (P = 0.022 and 0.020, respectively, in the older subset), perhaps related to improved neutrophil recovery, especially in patients who received a low total nucleated cell (TNC) dose (P = 0.031). Posttransplant relapse rate also tended to be reduced, especially in patients with myelogenous malignancies given units with a single HLA mismatch (P = 0.074). These findings represent unique evidence that donor exposure to NIMA can improve survival in unrelated CB transplantation and might reduce relapse, indicating that cord blood cells can mount an antileukemic effect. By matching for donor NIMAs in search algorithms of CB inventories, the probability of selecting a graft with an optimal outcome will increase significantly." @default.
• W2024234239 created "2016-06-24" @default.
• W2024234239 creator A5008439247 @default.
• W2024234239 creator A5042710656 @default.
• W2024234239 creator A5066032215 @default.
• W2024234239 creator A5072884857 @default.
• W2024234239 creator A5076154710 @default.
• W2024234239 creator A5085595407 @default.
• W2024234239 date "2009-11-24" @default.
• W2024234239 modified "2023-10-06" @default.
• W2024234239 title "Reexposure of cord blood to noninherited maternal HLA antigens improves transplant outcome in hematological malignancies" @default.
• W2024234239 cites W1274344746 @default.
• W2024234239 cites W1521169335 @default.
• W2024234239 cites W1521725625 @default.
• W2024234239 cites W1964082903 @default.
• W2024234239 cites W1965613868 @default.
• W2024234239 cites W1970490255 @default.
• W2024234239 cites W1976863674 @default.
• W2024234239 cites W1993448680 @default.
• W2024234239 cites W2010055592 @default.
• W2024234239 cites W2028784621 @default.
• W2024234239 cites W2036736974 @default.
• W2024234239 cites W2069630966 @default.
• W2024234239 cites W2072066004 @default.
• W2024234239 cites W2073696038 @default.
• W2024234239 cites W2076552449 @default.
• W2024234239 cites W2077047611 @default.
• W2024234239 cites W2085516849 @default.
• W2024234239 cites W2094501172 @default.
• W2024234239 cites W2102516973 @default.
• W2024234239 cites W2123365414 @default.
• W2024234239 cites W2124740402 @default.
• W2024234239 cites W2130663466 @default.
• W2024234239 cites W2135067231 @default.
• W2024234239 cites W2156835139 @default.
• W2024234239 cites W2167613058 @default.
• W2024234239 cites W2319640937 @default.
• W2024234239 cites W4246864212 @default.
• W2024234239 doi "https://doi.org/10.1073/pnas.0910310106" @default.
• W2024234239 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2775036" @default.
• W2024234239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19901324" @default.
• W2024234239 hasPublicationYear "2009" @default.
• W2024234239 type Work @default.
• W2024234239 sameAs 2024234239 @default.
• W2024234239 citedByCount "132" @default.
• W2024234239 countsByYear W20242342392012 @default.
• W2024234239 countsByYear W20242342392013 @default.
• W2024234239 countsByYear W20242342392014 @default.
• W2024234239 countsByYear W20242342392015 @default.
• W2024234239 countsByYear W20242342392016 @default.
• W2024234239 countsByYear W20242342392017 @default.
• W2024234239 countsByYear W20242342392018 @default.
• W2024234239 countsByYear W20242342392019 @default.
• W2024234239 countsByYear W20242342392020 @default.
• W2024234239 countsByYear W20242342392021 @default.
• W2024234239 countsByYear W20242342392022 @default.
• W2024234239 countsByYear W20242342392023 @default.
• W2024234239 crossrefType "journal-article" @default.
• W2024234239 hasAuthorship W2024234239A5008439247 @default.
• W2024234239 hasAuthorship W2024234239A5042710656 @default.
• W2024234239 hasAuthorship W2024234239A5066032215 @default.
• W2024234239 hasAuthorship W2024234239A5072884857 @default.
• W2024234239 hasAuthorship W2024234239A5076154710 @default.
• W2024234239 hasAuthorship W2024234239A5085595407 @default.
• W2024234239 hasBestOaLocation W20242342392 @default.
• W2024234239 hasConcept C126322002 @default.
• W2024234239 hasConcept C147483822 @default.
• W2024234239 hasConcept C188280979 @default.
• W2024234239 hasConcept C202965653 @default.
• W2024234239 hasConcept C203014093 @default.
• W2024234239 hasConcept C2777408962 @default.
• W2024234239 hasConcept C2780914630 @default.
• W2024234239 hasConcept C2911091166 @default.
• W2024234239 hasConcept C71924100 @default.
• W2024234239 hasConceptScore W2024234239C126322002 @default.
• W2024234239 hasConceptScore W2024234239C147483822 @default.
• W2024234239 hasConceptScore W2024234239C188280979 @default.
• W2024234239 hasConceptScore W2024234239C202965653 @default.
• W2024234239 hasConceptScore W2024234239C203014093 @default.
• W2024234239 hasConceptScore W2024234239C2777408962 @default.
• W2024234239 hasConceptScore W2024234239C2780914630 @default.
• W2024234239 hasConceptScore W2024234239C2911091166 @default.
• W2024234239 hasConceptScore W2024234239C71924100 @default.
• W2024234239 hasIssue "47" @default.
• W2024234239 hasLocation W20242342391 @default.
• W2024234239 hasLocation W20242342392 @default.
• W2024234239 hasLocation W20242342393 @default.
• W2024234239 hasLocation W20242342394 @default.
• W2024234239 hasOpenAccess W2024234239 @default.
• W2024234239 hasPrimaryLocation W20242342391 @default.
• W2024234239 hasRelatedWork W1615700017 @default.
• W2024234239 hasRelatedWork W1969366085 @default.
• W2024234239 hasRelatedWork W2052860239 @default.
• W2024234239 hasRelatedWork W2108167995 @default.
• W2024234239 hasRelatedWork W2324396282 @default.
• W2024234239 hasRelatedWork W2339331983 @default.
• W2024234239 hasRelatedWork W2978499815 @default.
• W2024234239 hasRelatedWork W2991049463 @default.

• next