FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024236133> ?p ?o ?g. }

• W2024236133 endingPage "452" @default.
• W2024236133 startingPage "441" @default.
• W2024236133 abstract "The multidrug resistant (MDR) transporter P-glycoprotein (P-gp) is constitutively expressed in normal tissues, where its spatial distribution defines it as an important element reducing the systemic exposure and tissue access of potentially harmful xenobiotics. We sought to determine whether P-gp is functionally expressed within alveolar epithelium of lung, in particular within the predominant cell type of this barrier, the alveolar epithelial (AE) type I cell. By immunohistochemistry, MDR-1/mdr-1 P-gp was localized to luminal membranes of AE type I epithelium within normal human and rat lung tissue. Using a primary rat cell culture model affording study of AE type II to AE type I differentiation, we observed increased expression (reverse transcription-polymerase chain reaction (RT-PCR), Western blot, and immunoflow cytometry techniques) of mdr-1a and mdr-1b P-gp in the cultures as they adopted an AE type I phenotype; freshly isolated AE type II cells were negative for mdr-1/P-gp. The functionality of P-gp within the AE cultures was demonstrated by a flow cytometric accumulation-retention assay using rhodamine-123 as substrate, and also by the polarized transport of vinblastine across confluent AE type I monolayers (basal-to-apical permeability was 3-fold that of apical-to-basal permeability), which was found to be comparable with the P-gp transport barrier presented by Caco-2 cell monolayers. The implications of localizing P-gp within alveolar epithelium is of significance to studies of fundamental respiratory cell biology as well as to further clarifying the nature of the barrier to xenobiotic transfer from alveolar airspace to pulmonary interstitium and capillary blood." @default.
• W2024236133 created "2016-06-24" @default.
• W2024236133 creator A5007749781 @default.
• W2024236133 creator A5038131272 @default.
• W2024236133 creator A5040308280 @default.
• W2024236133 creator A5042175465 @default.
• W2024236133 creator A5052464532 @default.
• W2024236133 creator A5057213428 @default.
• W2024236133 creator A5076511944 @default.
• W2024236133 date "2003-01-01" @default.
• W2024236133 modified "2023-10-13" @default.
• W2024236133 title "Constitutive Expression of P-Glycoprotein in Normal Lung Alveolar Epithelium and Functionality in Primary Alveolar Epithelial Cultures" @default.
• W2024236133 cites W1526950891 @default.
• W2024236133 cites W1765559903 @default.
• W2024236133 cites W1892943724 @default.
• W2024236133 cites W1966106234 @default.
• W2024236133 cites W1966718016 @default.
• W2024236133 cites W1969268496 @default.
• W2024236133 cites W1972334621 @default.
• W2024236133 cites W1992735863 @default.
• W2024236133 cites W1997850033 @default.
• W2024236133 cites W2005623678 @default.
• W2024236133 cites W2006814184 @default.
• W2024236133 cites W2011348241 @default.
• W2024236133 cites W2011798987 @default.
• W2024236133 cites W2015659645 @default.
• W2024236133 cites W2020943574 @default.
• W2024236133 cites W2023601946 @default.
• W2024236133 cites W2024357525 @default.
• W2024236133 cites W2030988632 @default.
• W2024236133 cites W2034777787 @default.
• W2024236133 cites W2048634673 @default.
• W2024236133 cites W2049520769 @default.
• W2024236133 cites W2073101361 @default.
• W2024236133 cites W2088453708 @default.
• W2024236133 cites W2090910729 @default.
• W2024236133 cites W2094365838 @default.
• W2024236133 cites W2095109810 @default.
• W2024236133 cites W2098142549 @default.
• W2024236133 cites W2112001901 @default.
• W2024236133 cites W2122216689 @default.
• W2024236133 cites W2125580352 @default.
• W2024236133 cites W2126392303 @default.
• W2024236133 cites W2141643423 @default.
• W2024236133 cites W2149456865 @default.
• W2024236133 cites W2160486989 @default.
• W2024236133 doi "https://doi.org/10.1124/jpet.102.042994" @default.
• W2024236133 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12490621" @default.
• W2024236133 hasPublicationYear "2003" @default.
• W2024236133 type Work @default.
• W2024236133 sameAs 2024236133 @default.
• W2024236133 citedByCount "96" @default.
• W2024236133 countsByYear W20242361332012 @default.
• W2024236133 countsByYear W20242361332013 @default.
• W2024236133 countsByYear W20242361332014 @default.
• W2024236133 countsByYear W20242361332015 @default.
• W2024236133 countsByYear W20242361332016 @default.
• W2024236133 countsByYear W20242361332017 @default.
• W2024236133 countsByYear W20242361332018 @default.
• W2024236133 countsByYear W20242361332019 @default.
• W2024236133 countsByYear W20242361332020 @default.
• W2024236133 countsByYear W20242361332021 @default.
• W2024236133 countsByYear W20242361332022 @default.
• W2024236133 countsByYear W20242361332023 @default.
• W2024236133 crossrefType "journal-article" @default.
• W2024236133 hasAuthorship W2024236133A5007749781 @default.
• W2024236133 hasAuthorship W2024236133A5038131272 @default.
• W2024236133 hasAuthorship W2024236133A5040308280 @default.
• W2024236133 hasAuthorship W2024236133A5042175465 @default.
• W2024236133 hasAuthorship W2024236133A5052464532 @default.
• W2024236133 hasAuthorship W2024236133A5057213428 @default.
• W2024236133 hasAuthorship W2024236133A5076511944 @default.
• W2024236133 hasConcept C104317684 @default.
• W2024236133 hasConcept C126322002 @default.
• W2024236133 hasConcept C133936738 @default.
• W2024236133 hasConcept C142724271 @default.
• W2024236133 hasConcept C1491633281 @default.
• W2024236133 hasConcept C153911025 @default.
• W2024236133 hasConcept C185592680 @default.
• W2024236133 hasConcept C189014844 @default.
• W2024236133 hasConcept C2776415932 @default.
• W2024236133 hasConcept C2777714996 @default.
• W2024236133 hasConcept C2778707650 @default.
• W2024236133 hasConcept C2909420118 @default.
• W2024236133 hasConcept C501593827 @default.
• W2024236133 hasConcept C529295009 @default.
• W2024236133 hasConcept C54355233 @default.
• W2024236133 hasConcept C553184892 @default.
• W2024236133 hasConcept C55493867 @default.
• W2024236133 hasConcept C71924100 @default.
• W2024236133 hasConcept C81885089 @default.
• W2024236133 hasConcept C86803240 @default.
• W2024236133 hasConcept C87568996 @default.
• W2024236133 hasConceptScore W2024236133C104317684 @default.
• W2024236133 hasConceptScore W2024236133C126322002 @default.
• W2024236133 hasConceptScore W2024236133C133936738 @default.
• W2024236133 hasConceptScore W2024236133C142724271 @default.
• W2024236133 hasConceptScore W2024236133C1491633281 @default.

• next