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- W2024237191 abstract "Abstract Isolated rat hearts beating intrinsic rhythm were perfused with balanced salt solution containing 0.15 m m albumin and glucose (11 m m ) or oleic acid (FFA/albumin molar ratio 2.65–4.65). After a control period (30 min) oxygen supply was restricted by lowering p O 2 from 700 to 140 mm Hg. After 20 min of oxygen restriction oxygenation was resumed. In all hearts coronary flow increased substantially during oxygen restriction and returned to approximately pre-restriction levels after reoxygenation. Contraction amplitude decreased during oxygen restriction and re-established itself only party after resuming oxygenation. Decrease was significantly greater and recovery significantly less in hearts perfused with oleic acid. Ventricular pre-mature beats (VPBs) were significantly more numerous in oleic acid hearts and occurred mainly shortly after starting reoxygenation. The incidence of other ventricular arrhythmias was also greater in these hearts. In hearts perfused with the combination oleic acid (FFA/albumin molar ratio 4.65) and glucose (11 m m ) incidence of VPBs was significantly lower and CA was much less depressed than in hearts perfused with oleic acid only. Apparently glucose protects the heart from the deleterious effects of oleic acid and oxygen restriction. Pyruvate (11 m m ) showed no protecting action in this respect. The difference in electrical and contractile behaviour between oxygen restricted hearts perfused with oleic acid and those perfused with glucose was even more striking when the hearts were paced (5/s) instead of beating intrinsic rhythm." @default.
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- W2024237191 title "Effects of oleic acid and oxygen restriction followed by re-oxygenation on rhythm and contractile activity of the isolated rat heart; protective action of glucose" @default.
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- W2024237191 doi "https://doi.org/10.1016/0022-2828(76)90042-0" @default.
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