Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024240141> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2024240141 endingPage "844" @default.
- W2024240141 startingPage "833" @default.
- W2024240141 abstract "Chinese herbal medicine has been used for thousands of years in China and other Asian countries to treat a variety of inflammatory diseases. The classic Chinese herbal formula, Huo Luo Xiao Ling Dan (活络效灵丹, HLXL) is commonly used in traditional Chinese herbal medicine for the treatment of joint pain and other symptoms of arthritis. The present study is an investigation of the effects of a modified HLXL extract on persistent hyperalgesia and edema in rats with peripheral inflammation. Inflammation was induced by injecting complete Freund's adjuvant (CFA) into one hind paw. Four dosages of the extract were compared to a vehicle control. Each was administered intragastrally (i.g.) daily for seven days beginning one day before CFA. Hyperalgesia was assessed using a paw withdrawal latency (PWL) test and edema was determined by measuring paw thickness at pre-CFA and 2 hours, 24 hours, and 5 days post-CFA. Immunohistochemistry was performed 2 hours post-CFA to determine spinal Fos protein expression. Adverse effects of the extract were monitored by observing the animals closely for unusual behavioral changes. Compared to the control, HLXL at the two lower dosages (0.575 g/kg and 1.15 g/kg) were effective in the later stage (day 5) of inflammatory hyperalgesia and edema, while the two higher dosages (2.3 g/kg and 4.6 g/kg) alleviated early stage hind paw inflammation and hyperalgesia and facilitated recovery from paw edema and hyperalgesia during the late stage. HLXL at 2.30 g/kg significantly suppressed Fos expression in laminae I–II, III–IV and V–VI ipsilaterally and in III-IV contralaterally. No significant signs of toxicity or adverse effects were observed. The data suggest that HLXL dosage-dependently attenuates CFA-induced inflammation and hyperalgesia, at least in part by inhibiting noxious transmission at the dorsal horn of the spinal cord." @default.
- W2024240141 created "2016-06-24" @default.
- W2024240141 creator A5000875207 @default.
- W2024240141 creator A5015198590 @default.
- W2024240141 creator A5016029838 @default.
- W2024240141 creator A5020648064 @default.
- W2024240141 creator A5023069485 @default.
- W2024240141 creator A5045421676 @default.
- W2024240141 creator A5049567539 @default.
- W2024240141 creator A5073872594 @default.
- W2024240141 date "2006-01-01" @default.
- W2024240141 modified "2023-09-27" @default.
- W2024240141 title "Anti-hyperalgesic and Anti-inflammatory Effects of the Modified Chinese Herbal Formula <i>Huo Luo Xiao Ling Dan</i> (HLXL) in Rats" @default.
- W2024240141 cites W2001026574 @default.
- W2024240141 cites W2003102216 @default.
- W2024240141 cites W2014007136 @default.
- W2024240141 cites W2061331313 @default.
- W2024240141 cites W2069446111 @default.
- W2024240141 cites W2080745413 @default.
- W2024240141 cites W2082937420 @default.
- W2024240141 cites W2085314445 @default.
- W2024240141 cites W2087454739 @default.
- W2024240141 cites W2129189215 @default.
- W2024240141 cites W4205092223 @default.
- W2024240141 cites W4248270717 @default.
- W2024240141 doi "https://doi.org/10.1142/s0192415x06004326" @default.
- W2024240141 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17080548" @default.
- W2024240141 hasPublicationYear "2006" @default.
- W2024240141 type Work @default.
- W2024240141 sameAs 2024240141 @default.
- W2024240141 citedByCount "31" @default.
- W2024240141 countsByYear W20242401412012 @default.
- W2024240141 countsByYear W20242401412013 @default.
- W2024240141 countsByYear W20242401412014 @default.
- W2024240141 countsByYear W20242401412015 @default.
- W2024240141 countsByYear W20242401412016 @default.
- W2024240141 countsByYear W20242401412017 @default.
- W2024240141 countsByYear W20242401412018 @default.
- W2024240141 countsByYear W20242401412019 @default.
- W2024240141 countsByYear W20242401412021 @default.
- W2024240141 countsByYear W20242401412022 @default.
- W2024240141 crossrefType "journal-article" @default.
- W2024240141 hasAuthorship W2024240141A5000875207 @default.
- W2024240141 hasAuthorship W2024240141A5015198590 @default.
- W2024240141 hasAuthorship W2024240141A5016029838 @default.
- W2024240141 hasAuthorship W2024240141A5020648064 @default.
- W2024240141 hasAuthorship W2024240141A5023069485 @default.
- W2024240141 hasAuthorship W2024240141A5045421676 @default.
- W2024240141 hasAuthorship W2024240141A5049567539 @default.
- W2024240141 hasAuthorship W2024240141A5073872594 @default.
- W2024240141 hasConcept C126322002 @default.
- W2024240141 hasConcept C15490471 @default.
- W2024240141 hasConcept C162156334 @default.
- W2024240141 hasConcept C170493617 @default.
- W2024240141 hasConcept C2776914184 @default.
- W2024240141 hasConcept C2779245659 @default.
- W2024240141 hasConcept C2780886150 @default.
- W2024240141 hasConcept C42219234 @default.
- W2024240141 hasConcept C556039675 @default.
- W2024240141 hasConcept C71924100 @default.
- W2024240141 hasConcept C98274493 @default.
- W2024240141 hasConceptScore W2024240141C126322002 @default.
- W2024240141 hasConceptScore W2024240141C15490471 @default.
- W2024240141 hasConceptScore W2024240141C162156334 @default.
- W2024240141 hasConceptScore W2024240141C170493617 @default.
- W2024240141 hasConceptScore W2024240141C2776914184 @default.
- W2024240141 hasConceptScore W2024240141C2779245659 @default.
- W2024240141 hasConceptScore W2024240141C2780886150 @default.
- W2024240141 hasConceptScore W2024240141C42219234 @default.
- W2024240141 hasConceptScore W2024240141C556039675 @default.
- W2024240141 hasConceptScore W2024240141C71924100 @default.
- W2024240141 hasConceptScore W2024240141C98274493 @default.
- W2024240141 hasIssue "05" @default.
- W2024240141 hasLocation W20242401411 @default.
- W2024240141 hasLocation W20242401412 @default.
- W2024240141 hasOpenAccess W2024240141 @default.
- W2024240141 hasPrimaryLocation W20242401411 @default.
- W2024240141 hasRelatedWork W1539519435 @default.
- W2024240141 hasRelatedWork W1661588959 @default.
- W2024240141 hasRelatedWork W1860085360 @default.
- W2024240141 hasRelatedWork W2002558453 @default.
- W2024240141 hasRelatedWork W2024240141 @default.
- W2024240141 hasRelatedWork W2085314445 @default.
- W2024240141 hasRelatedWork W2382016942 @default.
- W2024240141 hasRelatedWork W2393385943 @default.
- W2024240141 hasRelatedWork W3122706947 @default.
- W2024240141 hasRelatedWork W4380869850 @default.
- W2024240141 hasVolume "34" @default.
- W2024240141 isParatext "false" @default.
- W2024240141 isRetracted "false" @default.
- W2024240141 magId "2024240141" @default.
- W2024240141 workType "article" @default.