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• W2024241317 startingPage "308" @default.
• W2024241317 abstract "Stromal-cell-derived factor-1α (SDF-1α/CXCL12) is a potent chemoattractant for T cells. We report that Cbl family members, Cbl and Cbl-b, are tyrosine-phosphorylated after SDF-1α/CXCL12 stimulation of Jurkat T cells. Enhanced phosphorylation of Cbl and Cbl-b was regulated by src family kinases, and perhaps Fyn. Activated Cbl and Cbl-b interacted with Crk-L, Zap-70, Nck, PLC-γ and Fyb after SDF-1α/CXCL12 stimulation, implicating association of these proteins in SDF-1α/CXCL12 actions. SDF-1α/CXCL12 did not induce tyrosine phosphorylation of Cbl or Cbl-b in Lck-deficient T cell line J.CaM1.6 or CD45-deficient T cell line J45.01. Thus, Lck Src kinase and tyrosine phosphatase CD45 are likely involved in regulating activation of Cbl family members. A functional role for Cbl and Cbl-b in migration was demonstrated by the decrease in SDF-1/CXCL12-induced migration in a T cell line in which transfected small interfering RNA for Cbl and Cbl-b decreased expression of Cbl and Cbl-b, but not MAPK activity. SDF-1α/CXCL12-induced chemotaxis was greatly reduced in the CD45-deficient T cell line. Our results implicate CD45, Cbl, Cbl-b, src kinases and potentially other associated proteins as mediators of SDF-1α/CXCL12-induced cell migration of Jurkat T cells." @default.
• W2024241317 created "2016-06-24" @default.
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• W2024241317 date "2006-03-01" @default.
• W2024241317 modified "2023-10-03" @default.
• W2024241317 title "Stromal-cell-derived factor-1/CXCL12-induced chemotaxis of a T cell line involves intracellular signaling through Cbl and Cbl-b and their regulation by Src kinases and CD45" @default.
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• W2024241317 doi "https://doi.org/10.1016/j.bcmd.2005.12.035" @default.
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