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- W2024244035 abstract "Two previously reported water soluble 1,2-diaminocyclohexaneplatinum(II) antitumor complexes with nitrogen-containing dicarboxylato ligands (N-substituted iminodiacetato(1,2-diaminocyclohexane)platinum(II) and aminomalonato(1,2-diaminocyclohexane)platinum(II)) were discovered to have significant residual impurities in the chemical formulations. Upon further purification each complex was found to be significantly less active in biological systems than previously reported. Each complex is stable in aqueous solution. This experience suggests that commonly accepted criteria for chemical identification and purity are inadequate for this type of complex. We hypothesize that tridentate bonding between the nitrogen-containing dicarboxylato group and platinum renders these complexes chemically stable and biologically inert." @default.
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- W2024244035 date "1988-10-01" @default.
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- W2024244035 title "Water soluble DACHPt(II) complexes: Problems of purification; Stability of complexes with nitrogen-containing ligands" @default.
- W2024244035 cites W1996143201 @default.
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- W2024244035 doi "https://doi.org/10.1016/s0020-1693(00)83870-0" @default.
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