FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024244222> ?p ?o ?g. }

• W2024244222 endingPage "e70652" @default.
• W2024244222 startingPage "e70652" @default.
• W2024244222 abstract "Myosin II motors drive changes in focal adhesion morphology and composition in a “maturation process” that is crucial for regulating adhesion dynamics and signaling guiding cell adhesion, migration and fate. The underlying mechanisms of maturation, however, have been obscured by the intermingled effects of myosin II on lamellar actin architecture, dynamics and force transmission. Here, we show that focal adhesion growth rate stays constant even when cellular tension is reduced by 75%. Focal adhesion growth halts only when myosin stresses are sufficiently low to impair actin retrograde flow. Focal adhesion lifetime is reduced at low levels of cellular tension, but adhesion stability can be rescued at low levels of force by over-expression of α-actinin or constitutively active Dia1. Our work identifies a minimal myosin activity threshold that is necessary to drive lamellar actin retrograde flow is sufficient to permit focal adhesion elongation. Above this nominal threshold, myosin-mediated actin organization and dynamics regulate focal adhesion growth and stability in a force-insensitive fashion." @default.
• W2024244222 created "2016-06-24" @default.
• W2024244222 creator A5005425034 @default.
• W2024244222 creator A5043340480 @default.
• W2024244222 creator A5046539384 @default.
• W2024244222 creator A5059222904 @default.
• W2024244222 date "2013-07-29" @default.
• W2024244222 modified "2023-10-01" @default.
• W2024244222 title "Myosin II-Mediated Focal Adhesion Maturation Is Tension Insensitive" @default.
• W2024244222 cites W1969430572 @default.
• W2024244222 cites W1969964831 @default.
• W2024244222 cites W1970970501 @default.
• W2024244222 cites W1979038578 @default.
• W2024244222 cites W1987216547 @default.
• W2024244222 cites W1993006648 @default.
• W2024244222 cites W2027411306 @default.
• W2024244222 cites W2050612706 @default.
• W2024244222 cites W2060661444 @default.
• W2024244222 cites W2068888445 @default.
• W2024244222 cites W2069366060 @default.
• W2024244222 cites W2072435489 @default.
• W2024244222 cites W2079595896 @default.
• W2024244222 cites W2087624790 @default.
• W2024244222 cites W2109706035 @default.
• W2024244222 cites W2110834542 @default.
• W2024244222 cites W2112924183 @default.
• W2024244222 cites W2125644189 @default.
• W2024244222 cites W2130200852 @default.
• W2024244222 cites W2135165925 @default.
• W2024244222 cites W2141075109 @default.
• W2024244222 cites W2141141508 @default.
• W2024244222 cites W2148328620 @default.
• W2024244222 cites W2148454908 @default.
• W2024244222 cites W2150102283 @default.
• W2024244222 cites W2153626442 @default.
• W2024244222 cites W4246559328 @default.
• W2024244222 doi "https://doi.org/10.1371/journal.pone.0070652" @default.
• W2024244222 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3726642" @default.
• W2024244222 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23923013" @default.
• W2024244222 hasPublicationYear "2013" @default.
• W2024244222 type Work @default.
• W2024244222 sameAs 2024244222 @default.
• W2024244222 citedByCount "51" @default.
• W2024244222 countsByYear W20242442222014 @default.
• W2024244222 countsByYear W20242442222015 @default.
• W2024244222 countsByYear W20242442222016 @default.
• W2024244222 countsByYear W20242442222017 @default.
• W2024244222 countsByYear W20242442222018 @default.
• W2024244222 countsByYear W20242442222019 @default.
• W2024244222 countsByYear W20242442222020 @default.
• W2024244222 countsByYear W20242442222021 @default.
• W2024244222 countsByYear W20242442222022 @default.
• W2024244222 countsByYear W20242442222023 @default.
• W2024244222 crossrefType "journal-article" @default.
• W2024244222 hasAuthorship W2024244222A5005425034 @default.
• W2024244222 hasAuthorship W2024244222A5043340480 @default.
• W2024244222 hasAuthorship W2024244222A5046539384 @default.
• W2024244222 hasAuthorship W2024244222A5059222904 @default.
• W2024244222 hasBestOaLocation W20242442221 @default.
• W2024244222 hasConcept C108391706 @default.
• W2024244222 hasConcept C12554922 @default.
• W2024244222 hasConcept C125705527 @default.
• W2024244222 hasConcept C142669718 @default.
• W2024244222 hasConcept C1491633281 @default.
• W2024244222 hasConcept C151166631 @default.
• W2024244222 hasConcept C178790620 @default.
• W2024244222 hasConcept C185592680 @default.
• W2024244222 hasConcept C195794163 @default.
• W2024244222 hasConcept C2993400109 @default.
• W2024244222 hasConcept C55493867 @default.
• W2024244222 hasConcept C62478195 @default.
• W2024244222 hasConcept C6997183 @default.
• W2024244222 hasConcept C84416704 @default.
• W2024244222 hasConcept C85789140 @default.
• W2024244222 hasConcept C86803240 @default.
• W2024244222 hasConcept C90934575 @default.
• W2024244222 hasConcept C95444343 @default.
• W2024244222 hasConceptScore W2024244222C108391706 @default.
• W2024244222 hasConceptScore W2024244222C12554922 @default.
• W2024244222 hasConceptScore W2024244222C125705527 @default.
• W2024244222 hasConceptScore W2024244222C142669718 @default.
• W2024244222 hasConceptScore W2024244222C1491633281 @default.
• W2024244222 hasConceptScore W2024244222C151166631 @default.
• W2024244222 hasConceptScore W2024244222C178790620 @default.
• W2024244222 hasConceptScore W2024244222C185592680 @default.
• W2024244222 hasConceptScore W2024244222C195794163 @default.
• W2024244222 hasConceptScore W2024244222C2993400109 @default.
• W2024244222 hasConceptScore W2024244222C55493867 @default.
• W2024244222 hasConceptScore W2024244222C62478195 @default.
• W2024244222 hasConceptScore W2024244222C6997183 @default.
• W2024244222 hasConceptScore W2024244222C84416704 @default.
• W2024244222 hasConceptScore W2024244222C85789140 @default.
• W2024244222 hasConceptScore W2024244222C86803240 @default.
• W2024244222 hasConceptScore W2024244222C90934575 @default.
• W2024244222 hasConceptScore W2024244222C95444343 @default.
• W2024244222 hasIssue "7" @default.
• W2024244222 hasLocation W20242442221 @default.
• W2024244222 hasLocation W20242442222 @default.

• next