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• W2024246772 abstract "To examine the acute effects of NO-synthase inhibition on renal hemodynamics in normotensive and hypertensive subjects.Changes of renal plasma flow (RPF) and glomerular filtration rate (GFR) in response to intravenous infusions of NG-monomethyl-l-arginine (l-NMMA) (3 mg/kg per 30 min) were measured in 32 normotensive and in 39 essential hypertensive patients by use of clearance technique.l-NMMA significantly decreased RPF in normotensive and hypertensive individuals (P < 0.001), while GFR was preserved. Changes of renal hemodynamic parameters were similar in hypertensive and normotensive subjects (deltaRPF: -88 +/- 89 versus -81 +/- 105 ml/min, P = NS; deltaGFR 1.6 +/- 8.2 versus 4.3 +/- 8.9 ml/min, P = NS) Furthermore, l-NMMA increased mean arterial pressure (deltaMAP 5.3 +/- 6.3 versus 6.0 +/- 6.1 mmHg, P = NS) and decreased heart rate (deltaHR -5.8 +/- 3.9 versus -4.1 +/- 3.8 beats/min, P = NS) to a similar extent in both groups.Basal NO synthesis of the renal vasculature is not impaired in patients with established essential hypertension." @default.
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• W2024246772 date "2002-03-01" @default.
• W2024246772 modified "2023-09-22" @default.
• W2024246772 title "Impact of NO-synthase inhibition on renal hemodynamics in normotensive and hypertensive subjects" @default.
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• W2024246772 doi "https://doi.org/10.1097/00004872-200203000-00029" @default.
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