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- W2024246986 abstract "Because many women who receive pharmacologic therapy with antidepressants are also prescribed oral contraceptives, it is important to assess the risk of clinically significant drug interactions. We reviewed the United States fluoxetine clinical trial database, specifically analyzing women ages 18 to 45 years, for differences in safety, antidepressant efficacy, and unplanned pregnancies that were associated with oral contraceptive use.Data from 17 double-blind, placebo-controlled clinical trials in 1698 women were analyzed retrospectively. A subgroup of women with oral contraceptive use was compared with a subgroup of women with no oral contraceptive use. Differences in treatment-emergent adverse events, unplanned pregnancies, and 17-item Hamilton Depression Scale (HAMD-17) scores were analyzed.The only treatment-emergent adverse events that showed a statistically significantly different odds ratio for oral contraceptive use versus no oral contraceptive use were headache, asthenia, and pain. There was not a statistically significant interaction in the incidence of unintended pregnancies (P =.111) or in the changes from baseline in HAMDD-17 scores.There is no clinical evidence that concomitant use of oral contraceptives and fluoxetine affects the safety or efficacy of either agent." @default.
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- W2024246986 date "2002-09-01" @default.
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- W2024246986 title "Safety and efficacy of fluoxetine in patients who receive oral contraceptive therapy" @default.
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- W2024246986 doi "https://doi.org/10.1067/mob.2002.124939" @default.
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