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- W2024247130 abstract "Abstract The production and accumulation of potent anticholinesterase metabolites when parathion [ o,o -diethyl o -(4-nitrophenyl) phosphorothionate] and Guthion [ o,o ,-dimethyl s -(4 oxo-1,2,3-benzotriazin-3(4 H )-ylmethyl) phosphorodithioate] were incubated with liver homogenates or cell fractions from 3 mammalian, 2 avian, and 2 fish species was studied. Comparison of activation of the phosphorothionates by whole liver homogenates without added cofactors and in the presence of NAD, NADP, or NADP plus glucose 6-phosphate showed that for all species maximum activation was obtained in the presence of NAPD plus glucose 6-phosphate, although in a few cases NAD alone was equally effective. For all species half or more of the phosphorothionate activation activity of whole liver homogenates was recovered in the 8500 g supernatant fractions, but because of species differences in the relative activity of different fractions, it appears that whole homogenates are most useful for comparative studies. Activity was present in the washed microsomal fraction of all species, except flounder liver, when reduced NADP was added. There appeared to be some species differences in the stability of the phosphorothionate activating system when homogenates were stored at different temperatures. Tests on whole liver homogenates from several animals of each species yielded the following general order of activation: mammals > birds > fish." @default.
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- W2024247130 date "1971-05-01" @default.
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- W2024247130 title "Activation of parathion and guthion by mammalian, avian, and piscine liver homogenates and cell fractions" @default.
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- W2024247130 doi "https://doi.org/10.1016/0041-008x(71)90187-6" @default.
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