FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024248637> ?p ?o ?g. }

• W2024248637 endingPage "144" @default.
• W2024248637 startingPage "137" @default.
• W2024248637 abstract "West Nile virus (WNV) NS2B–NS3 protease is an important drug target since it is an essential protein for the replication of the virus. In order to determine the minimum pharmacophore for protease inhibition, a series of dipeptide aldehydes were synthesized. The 50% inhibitory concentration (IC50) measurements revealed that a simple acetyl-KR-aldehyde was only threefold less active than 4-phenyl-phenylacetyl-KKR-aldehyde (1) (Stoermer et al., 2008) that was used as the reference compound. The ligand efficiency of 0.40 kcal/mol/HA (HA = heavy atom) for acetyl-KR-aldehyde is much improved compared to the reference compound 1 (0.23 kcal/mol/HA). The binding of the inhibitors was examined using 1H-15N-HSQC experiments and differential chemical shifts were used to map the ligand binding sites. The biophysical studies show that the conformational mobility of WNV protease has a major impact on the design of novel inhibitors, since the protein conformation changes profoundly depending on the structure of the bound ligand." @default.
• W2024248637 created "2016-06-24" @default.
• W2024248637 creator A5013828600 @default.
• W2024248637 creator A5022053399 @default.
• W2024248637 creator A5023838903 @default.
• W2024248637 creator A5029269398 @default.
• W2024248637 creator A5036088778 @default.
• W2024248637 creator A5036977106 @default.
• W2024248637 creator A5050600149 @default.
• W2024248637 creator A5051005294 @default.
• W2024248637 creator A5051284876 @default.
• W2024248637 creator A5065088638 @default.
• W2024248637 creator A5065527770 @default.
• W2024248637 creator A5071922835 @default.
• W2024248637 creator A5075159369 @default.
• W2024248637 date "2013-02-01" @default.
• W2024248637 modified "2023-10-02" @default.
• W2024248637 title "Exploring the binding of peptidic West Nile virus NS2B–NS3 protease inhibitors by NMR" @default.
• W2024248637 cites W1968353490 @default.
• W2024248637 cites W1972091733 @default.
• W2024248637 cites W1995667567 @default.
• W2024248637 cites W2004807281 @default.
• W2024248637 cites W2008525757 @default.
• W2024248637 cites W2023582466 @default.
• W2024248637 cites W2028064829 @default.
• W2024248637 cites W2040446474 @default.
• W2024248637 cites W2044749643 @default.
• W2024248637 cites W2054881399 @default.
• W2024248637 cites W2062253359 @default.
• W2024248637 cites W2074188269 @default.
• W2024248637 cites W2088848851 @default.
• W2024248637 cites W2089210389 @default.
• W2024248637 cites W2091265811 @default.
• W2024248637 cites W2092381880 @default.
• W2024248637 cites W2094022774 @default.
• W2024248637 cites W2095368791 @default.
• W2024248637 cites W2107739206 @default.
• W2024248637 cites W2112418305 @default.
• W2024248637 cites W2140369033 @default.
• W2024248637 cites W2147281292 @default.
• W2024248637 cites W2154155208 @default.
• W2024248637 cites W2156549482 @default.
• W2024248637 cites W2158728104 @default.
• W2024248637 cites W2169821755 @default.
• W2024248637 cites W361482293 @default.
• W2024248637 doi "https://doi.org/10.1016/j.antiviral.2012.11.008" @default.
• W2024248637 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23211132" @default.
• W2024248637 hasPublicationYear "2013" @default.
• W2024248637 type Work @default.
• W2024248637 sameAs 2024248637 @default.
• W2024248637 citedByCount "31" @default.
• W2024248637 countsByYear W20242486372013 @default.
• W2024248637 countsByYear W20242486372014 @default.
• W2024248637 countsByYear W20242486372015 @default.
• W2024248637 countsByYear W20242486372016 @default.
• W2024248637 countsByYear W20242486372017 @default.
• W2024248637 countsByYear W20242486372018 @default.
• W2024248637 countsByYear W20242486372019 @default.
• W2024248637 countsByYear W20242486372020 @default.
• W2024248637 countsByYear W20242486372021 @default.
• W2024248637 countsByYear W20242486372022 @default.
• W2024248637 crossrefType "journal-article" @default.
• W2024248637 hasAuthorship W2024248637A5013828600 @default.
• W2024248637 hasAuthorship W2024248637A5022053399 @default.
• W2024248637 hasAuthorship W2024248637A5023838903 @default.
• W2024248637 hasAuthorship W2024248637A5029269398 @default.
• W2024248637 hasAuthorship W2024248637A5036088778 @default.
• W2024248637 hasAuthorship W2024248637A5036977106 @default.
• W2024248637 hasAuthorship W2024248637A5050600149 @default.
• W2024248637 hasAuthorship W2024248637A5051005294 @default.
• W2024248637 hasAuthorship W2024248637A5051284876 @default.
• W2024248637 hasAuthorship W2024248637A5065088638 @default.
• W2024248637 hasAuthorship W2024248637A5065527770 @default.
• W2024248637 hasAuthorship W2024248637A5071922835 @default.
• W2024248637 hasAuthorship W2024248637A5075159369 @default.
• W2024248637 hasConcept C116569031 @default.
• W2024248637 hasConcept C132379496 @default.
• W2024248637 hasConcept C159047783 @default.
• W2024248637 hasConcept C161790260 @default.
• W2024248637 hasConcept C170493617 @default.
• W2024248637 hasConcept C181199279 @default.
• W2024248637 hasConcept C185592680 @default.
• W2024248637 hasConcept C202751555 @default.
• W2024248637 hasConcept C2522874641 @default.
• W2024248637 hasConcept C2776714187 @default.
• W2024248637 hasConcept C2776866189 @default.
• W2024248637 hasConcept C2777752497 @default.
• W2024248637 hasConcept C2779138802 @default.
• W2024248637 hasConcept C2779281246 @default.
• W2024248637 hasConcept C2779825165 @default.
• W2024248637 hasConcept C41183919 @default.
• W2024248637 hasConcept C55493867 @default.
• W2024248637 hasConcept C56173144 @default.
• W2024248637 hasConcept C71240020 @default.
• W2024248637 hasConcept C86803240 @default.
• W2024248637 hasConceptScore W2024248637C116569031 @default.
• W2024248637 hasConceptScore W2024248637C132379496 @default.
• W2024248637 hasConceptScore W2024248637C159047783 @default.

• next