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• W2024251150 abstract "Abstract The structural and functional organization of the human cingulate cortex is an ongoing focus; however, human imaging studies continue to use the century‐old Brodmann concept of a two region cingulate cortex. Recently, a four‐region neurobiological model was proposed based on structural, circuitry, and functional imaging observations. It encompasses the anterior cingulate, midcingulate, posterior cingulate, and retrosplenial cortices (ACC, MCC, PCC, and RSC, respectively). For the first time, this study performs multireceptor autoradiography of 15 neurotransmitter receptor ligands and multivariate statistics on human whole brain postmortem samples covering the entire cingulate cortex. We evaluated the validity of Brodmann's duality concept and of the four‐region model using a hierarchical clustering analysis of receptor binding according to the degree of similarity of each area's receptor architecture. We could not find support for Brodmann's dual cingulate concept, because the anterior part of his area 24 has significantly higher AMPA, kainate, GABA B , benzodiazepine, and M 3 but lower NMDA and GABA A binding site densities than the posterior part. The hierarchical clustering analysis distinguished ACC, MCC, PCC, and RSC as independent regions. The ACC has highest AMPA, kainate, α 2 , 5‐HT 1A , and D 1 but lowest GABA A densities. The MCC has lowest AMPA, kainate, α 2 , and D 1 densities. Area 25 in ACC is similar in receptor‐architecture to MCC, particularly the NMDA, GABA A , GABA B , and M 2 receptors. The PCC and RSC differ in the higher M 1 and α 1 but lower M 3 densities of PCC. Thus, multireceptor autoradiography supports the four‐region neurobiological model of the cingulate cortex. Hum Brain Mapp, 2009. © 2008 Wiley‐Liss, Inc." @default.
• W2024251150 created "2016-06-24" @default.
• W2024251150 creator A5026199142 @default.
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• W2024251150 creator A5088672808 @default.
• W2024251150 date "2008-11-25" @default.
• W2024251150 modified "2023-10-16" @default.
• W2024251150 title "Receptor architecture of human cingulate cortex: Evaluation of the four-region neurobiological model" @default.
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• W2024251150 doi "https://doi.org/10.1002/hbm.20667" @default.
• W2024251150 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6870973" @default.
• W2024251150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19034899" @default.
• W2024251150 hasPublicationYear "2008" @default.

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