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- W2024251319 abstract "1. Vasodilating prostaglandins were injected, in bolus doses, into the lower abdominal aorta or left circumflex coronary artery (LCCA) of conscious sheep. 2. Local blood flow. mean arterial pressure (MAP), heart rate (HR) and ECG were monitored continuously. 3. 6-Keto PGF1α had no effect on either vascular bed in doses up to 100 μg. PGE2 was more potent than PGI2in dilating hindlimb vasculature and PGE2 induced a more persistent hyperaemia whereas PGD2 elicited a biphasic response (constriction -dilation). 4. PGE1, PGE2, PGD2 and PGI2 all produced dose-dependent vasodilation, the order of potency being PGD2 > PGI2>PGE1⩾ PGE2. The effect of PGI2 was more transient and PGE1 and PGD2 caused small but consistent decreases in MAP and HR, respectively." @default.
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- W2024251319 date "1986-01-01" @default.
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- W2024251319 title "The effects of certain vasodilating prostaglandins on the coronary and hindlimb vascular beds of the conscious sheep" @default.
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- W2024251319 doi "https://doi.org/10.1016/0742-8413(86)90143-x" @default.
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