Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024251369> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2024251369 endingPage "154" @default.
- W2024251369 startingPage "152" @default.
- W2024251369 abstract "Cholestasis develops as a consequence of impaired bile formation and/or bile flow and can be classified as intra- or extrahepatic. Chronic cholestatic diseases are mostly intrahepatic with the exception of primary and secondary sclerosing cholangitis affecting intra- and extrahepatic bile ducts. Recent genome-wide association studies have confirmed major histocompatibility complex associations and discovered multiple susceptibility loci in primary biliary cirrhosis and primary sclerosing cholangitis, providing new insights into disease pathogenesis, which may translate into more precise therapeutic prevention and intervention in the future. Diagnostic steps in cholestatic conditions comprise a thorough patient history, abdominal imaging and distinct serological studies including antimitochondrial antibodies and IgG4 levels; if the diagnosis remains unclear, liver biopsy is warranted. Genetic testing should also be considered, as mutations in the hepatobiliary transporters <i>ATP8B1</i>,<i> ABCB11 </i>and<i> ABCB4 </i>are causative for three different forms of familial intrahepatic cholestasis. Disease severity is dependent on the genotypic variants of these transporters, ranging from mildly elevated liver enzymes in adults to cirrhosis in early childhood. Ligands of nuclear receptors, which represent important regulators of hepatobiliary transporters, and modified bile salts are new promising therapeutic options in cholestatic liver disease and are currently being investigated in clinical trials." @default.
- W2024251369 created "2016-06-24" @default.
- W2024251369 creator A5013003026 @default.
- W2024251369 creator A5044484875 @default.
- W2024251369 date "2013-01-01" @default.
- W2024251369 modified "2023-10-09" @default.
- W2024251369 title "Cholestatic Liver Disease" @default.
- W2024251369 cites W2022671971 @default.
- W2024251369 cites W2037842760 @default.
- W2024251369 cites W2038811020 @default.
- W2024251369 cites W2067771268 @default.
- W2024251369 cites W2078657636 @default.
- W2024251369 cites W2079146831 @default.
- W2024251369 cites W2080304201 @default.
- W2024251369 cites W2089132377 @default.
- W2024251369 cites W2131894220 @default.
- W2024251369 cites W2143286837 @default.
- W2024251369 cites W2153400655 @default.
- W2024251369 cites W2161224665 @default.
- W2024251369 cites W2323030281 @default.
- W2024251369 cites W2328865893 @default.
- W2024251369 cites W2786456523 @default.
- W2024251369 cites W3140754719 @default.
- W2024251369 doi "https://doi.org/10.1159/000347210" @default.
- W2024251369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23797137" @default.
- W2024251369 hasPublicationYear "2013" @default.
- W2024251369 type Work @default.
- W2024251369 sameAs 2024251369 @default.
- W2024251369 citedByCount "31" @default.
- W2024251369 countsByYear W20242513692014 @default.
- W2024251369 countsByYear W20242513692015 @default.
- W2024251369 countsByYear W20242513692016 @default.
- W2024251369 countsByYear W20242513692017 @default.
- W2024251369 countsByYear W20242513692018 @default.
- W2024251369 countsByYear W20242513692019 @default.
- W2024251369 countsByYear W20242513692020 @default.
- W2024251369 countsByYear W20242513692021 @default.
- W2024251369 countsByYear W20242513692022 @default.
- W2024251369 countsByYear W20242513692023 @default.
- W2024251369 crossrefType "journal-article" @default.
- W2024251369 hasAuthorship W2024251369A5013003026 @default.
- W2024251369 hasAuthorship W2024251369A5044484875 @default.
- W2024251369 hasConcept C126322002 @default.
- W2024251369 hasConcept C2775934546 @default.
- W2024251369 hasConcept C2777075537 @default.
- W2024251369 hasConcept C2777214474 @default.
- W2024251369 hasConcept C2777766500 @default.
- W2024251369 hasConcept C2778132995 @default.
- W2024251369 hasConcept C2778593092 @default.
- W2024251369 hasConcept C2779134260 @default.
- W2024251369 hasConcept C2779609443 @default.
- W2024251369 hasConcept C2779777945 @default.
- W2024251369 hasConcept C2780366471 @default.
- W2024251369 hasConcept C2780615123 @default.
- W2024251369 hasConcept C2780788601 @default.
- W2024251369 hasConcept C2780942790 @default.
- W2024251369 hasConcept C2780965833 @default.
- W2024251369 hasConcept C2911091166 @default.
- W2024251369 hasConcept C71924100 @default.
- W2024251369 hasConcept C90924648 @default.
- W2024251369 hasConceptScore W2024251369C126322002 @default.
- W2024251369 hasConceptScore W2024251369C2775934546 @default.
- W2024251369 hasConceptScore W2024251369C2777075537 @default.
- W2024251369 hasConceptScore W2024251369C2777214474 @default.
- W2024251369 hasConceptScore W2024251369C2777766500 @default.
- W2024251369 hasConceptScore W2024251369C2778132995 @default.
- W2024251369 hasConceptScore W2024251369C2778593092 @default.
- W2024251369 hasConceptScore W2024251369C2779134260 @default.
- W2024251369 hasConceptScore W2024251369C2779609443 @default.
- W2024251369 hasConceptScore W2024251369C2779777945 @default.
- W2024251369 hasConceptScore W2024251369C2780366471 @default.
- W2024251369 hasConceptScore W2024251369C2780615123 @default.
- W2024251369 hasConceptScore W2024251369C2780788601 @default.
- W2024251369 hasConceptScore W2024251369C2780942790 @default.
- W2024251369 hasConceptScore W2024251369C2780965833 @default.
- W2024251369 hasConceptScore W2024251369C2911091166 @default.
- W2024251369 hasConceptScore W2024251369C71924100 @default.
- W2024251369 hasConceptScore W2024251369C90924648 @default.
- W2024251369 hasIssue "1" @default.
- W2024251369 hasLocation W20242513691 @default.
- W2024251369 hasLocation W20242513692 @default.
- W2024251369 hasOpenAccess W2024251369 @default.
- W2024251369 hasPrimaryLocation W20242513691 @default.
- W2024251369 hasRelatedWork W173203827 @default.
- W2024251369 hasRelatedWork W2149047916 @default.
- W2024251369 hasRelatedWork W2167308360 @default.
- W2024251369 hasRelatedWork W2330595729 @default.
- W2024251369 hasRelatedWork W2364132123 @default.
- W2024251369 hasRelatedWork W4233745628 @default.
- W2024251369 hasRelatedWork W4239173214 @default.
- W2024251369 hasRelatedWork W4249476423 @default.
- W2024251369 hasRelatedWork W4251123449 @default.
- W2024251369 hasRelatedWork W4255852741 @default.
- W2024251369 hasVolume "31" @default.
- W2024251369 isParatext "false" @default.
- W2024251369 isRetracted "false" @default.
- W2024251369 magId "2024251369" @default.
- W2024251369 workType "article" @default.