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• W2024252037 endingPage "459" @default.
• W2024252037 startingPage "449" @default.
• W2024252037 abstract "Reproductive toxicity encompasses harmful effects of various agents on all aspects and stages of the reproductive cycle, including infertility and the induction of adverse effects in the embryo/fetus. In developing a model for reproductive toxicity screening, it is important to define the stage of the human reproductive cycle that this specific model is going to recreate in vitro and to identify molecular targets that are critical for this stage of development. In this review, we focus our discussion on modeling pre-implantation embryotoxicity. The rationale for this is that despite advances on both clinical and biological levels, many unresolved infertility cases may be due to our lack of knowledge regarding environmental influences on this short, but critical stage of development. Data from in vitro fertilization practice suggest that the early-dividing embryo is very sensitive to numerous factors present in its microenvironment. In vivo, as the embryo travels down the oviduct, physical or chemical insults can directly damage the embryo and/or prevent implantation, and cause infertility. Multiple lines of evidence point to the differences between mouse and human pre-implantation development and between mouse and human embryonic stem cells (hESCs). In light of these data we present the case that hESCs and their derivatives are better suited as in vitro models for human pre-implantation development than their mouse counterparts. We then describe some of the most promising hESC-based systems that are used today to model certain aspects of development in the human pre-implantation embryo and that have the potential to be used for embryo toxicity screening tests in the near future. Described systems model two major events during differentiation of the human pre-implantation embryo: differentiation of the trophectoderm and segregation of the inner cell mass into epiblast and hypoblast. The first event is replicated in vitro by triggering either direct or indirect (through embryoid body stage) differentiation into trophectoderm. The second event can be modeled using the recently described system of high-throughput generation of embryoid bodies that recapitulate segregation of inner cell mass. We conclude by discussing the potential of these existing models in toxicology studies and the possibilities for their improvement in the future." @default.
• W2024252037 created "2016-06-24" @default.
• W2024252037 creator A5003944534 @default.
• W2024252037 creator A5010037572 @default.
• W2024252037 creator A5062453240 @default.
• W2024252037 creator A5085747842 @default.
• W2024252037 date "2009-05-01" @default.
• W2024252037 modified "2023-10-12" @default.
• W2024252037 title "Human embryonic stem cells as a model for embryotoxicity screening" @default.
• W2024252037 cites W1821797507 @default.
• W2024252037 cites W1964405000 @default.
• W2024252037 cites W1965461792 @default.
• W2024252037 cites W1965674737 @default.
• W2024252037 cites W1967064280 @default.
• W2024252037 cites W1969117475 @default.
• W2024252037 cites W1973727308 @default.
• W2024252037 cites W1973876456 @default.
• W2024252037 cites W1975751233 @default.
• W2024252037 cites W1980243879 @default.
• W2024252037 cites W1981457253 @default.
• W2024252037 cites W1986516415 @default.
• W2024252037 cites W1988671949 @default.
• W2024252037 cites W1991633473 @default.
• W2024252037 cites W1993419284 @default.
• W2024252037 cites W1994248946 @default.
• W2024252037 cites W1999383862 @default.
• W2024252037 cites W2002555966 @default.
• W2024252037 cites W2003874140 @default.
• W2024252037 cites W2004791359 @default.
• W2024252037 cites W2009473720 @default.
• W2024252037 cites W2012777643 @default.
• W2024252037 cites W2012899237 @default.
• W2024252037 cites W2013392344 @default.
• W2024252037 cites W2014909814 @default.
• W2024252037 cites W2019205168 @default.
• W2024252037 cites W2020475324 @default.
• W2024252037 cites W2020833650 @default.
• W2024252037 cites W2022399725 @default.
• W2024252037 cites W2024585440 @default.
• W2024252037 cites W2025233095 @default.
• W2024252037 cites W2026597345 @default.
• W2024252037 cites W2030406325 @default.
• W2024252037 cites W2032665278 @default.
• W2024252037 cites W2032806930 @default.
• W2024252037 cites W2045388302 @default.
• W2024252037 cites W2046573256 @default.
• W2024252037 cites W2046589688 @default.
• W2024252037 cites W2051848511 @default.
• W2024252037 cites W2054280836 @default.
• W2024252037 cites W2055358183 @default.
• W2024252037 cites W2056089399 @default.
• W2024252037 cites W2057677145 @default.
• W2024252037 cites W2061004792 @default.
• W2024252037 cites W2071953998 @default.
• W2024252037 cites W2072177711 @default.
• W2024252037 cites W2072569268 @default.
• W2024252037 cites W2073797037 @default.
• W2024252037 cites W2075084906 @default.
• W2024252037 cites W2076794349 @default.
• W2024252037 cites W2078576043 @default.
• W2024252037 cites W2079097460 @default.
• W2024252037 cites W2082186027 @default.
• W2024252037 cites W2083763893 @default.
• W2024252037 cites W2087789903 @default.
• W2024252037 cites W2089253191 @default.
• W2024252037 cites W2091350790 @default.
• W2024252037 cites W2094557730 @default.
• W2024252037 cites W2096326024 @default.
• W2024252037 cites W2096430572 @default.
• W2024252037 cites W2096565553 @default.
• W2024252037 cites W2096791965 @default.
• W2024252037 cites W2100836767 @default.
• W2024252037 cites W2102175828 @default.
• W2024252037 cites W2104155874 @default.
• W2024252037 cites W2106087857 @default.
• W2024252037 cites W2109556015 @default.
• W2024252037 cites W2109881276 @default.
• W2024252037 cites W2113118410 @default.
• W2024252037 cites W2118852675 @default.
• W2024252037 cites W2123019895 @default.
• W2024252037 cites W2123159256 @default.
• W2024252037 cites W2124303397 @default.
• W2024252037 cites W2124603532 @default.
• W2024252037 cites W2124726835 @default.
• W2024252037 cites W2134809409 @default.
• W2024252037 cites W2136213798 @default.
• W2024252037 cites W2142001424 @default.
• W2024252037 cites W2149146453 @default.
• W2024252037 cites W2155197966 @default.
• W2024252037 cites W2162142896 @default.
• W2024252037 cites W2167196101 @default.
• W2024252037 cites W2168902374 @default.
• W2024252037 cites W27814405 @default.
• W2024252037 cites W2897611373 @default.
• W2024252037 cites W3022419230 @default.
• W2024252037 doi "https://doi.org/10.2217/rme.09.13" @default.
• W2024252037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19438319" @default.
• W2024252037 hasPublicationYear "2009" @default.

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