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• W2024252214 abstract "To investigate whether high glucose stimulates the expression of inflammatory cytokines and the possible mechanisms involved. ELISA and real-time PCR were used to determine the expression of the inflammatory factors, and a chemiluminescence assay was used to measure the production of reactive oxygen species (ROS). Compared to low glucose (10 mmol/L), treatment with high glucose (35 mmol/L) increased the secretion of tumor necrosis factor (TNF)α and monocyte chemotactic protein-1 (MCP-1), but not interleukin (IL)-1β and IL-6, in a time-dependent manner in primary cultured rat microglia. The mRNA expression of TNFα and MCP-1 also increased in response to high glucose. This upregulation was specific to high glucose because it was not observed in the osmotic control. High-glucose treatment stimulated the formation of ROS. Furthermore, treatment with the ROS scavenger NAC significantly reduced the high glucose-induced TNFα and MCP-1 secretion. In addition, the nuclear factor kappa B (NF-κB) inhibitors MG132 and PDTC completely blocked the high glucose-induced TNFα and MCP-1 secretion. We found that high glucose induces TNFα and MCP-1 secretion as well as mRNA expression in rat microglia in vitro, and this effect is mediated by the ROS and NF-κB pathways." @default.
• W2024252214 created "2016-06-24" @default.
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• W2024252214 date "2011-02-01" @default.
• W2024252214 modified "2023-10-05" @default.
• W2024252214 title "High glucose stimulates TNFα and MCP-1 expression in rat microglia via ROS and NF-κB pathways" @default.
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• W2024252214 doi "https://doi.org/10.1038/aps.2010.174" @default.
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