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• W2024252318 abstract "Lymph nodes from 21 cases of malignant lymphoma of a centrocytic (mantle cell) type, (ML, cc (mc)) were examined. All the cases had monoclonal surface immunoglobulin (sig) M and/or D, but were negative for CD 10 (CALLA), and CD11c (LeuM5). Lymphoma cells with CD25 (anti-Tac)+, CD5 (Leu1)+, and alkaline phosphatase (ALPase)-in eight cases showed bone marrow involvement (10–66% of the nucleated cells; mean 32± 18%) but with no leukemic changes. These eight cases has a similar phenotype and were distributed by the lymphoma cells to the examined B-chronic lymphocytic leukemia. Seven cases showed an infiltration of CD25-, CD5+, and AL Pase- lymphoma cells, in which only two cases showed focal bone marrow involvement.There was a close relationship between CD25 expression and bone marrow invasion by the lymphoma cells in ML, cc(mc). Three of the six CD25- and CD5- cases presented zonal proliferation of AlPase+ lymphoma cells with round nuciee and a high anti-proliferating cell nuclear antigen/cyclin (PCNA/c) rate in the mantle zone and paracortex, accompanied by a prominent interdigitating dendritic and histiocytic cell reaction. Examined CD25-, CD5- and ALPase+ lymphoma showed a neoplastic counterpart of so-called marginal zone lymphocytes, which was different from other cases of ML, cc (mc). Lymphoma cells in ML, cc(mc), except for those of the so-called marginal zone lymphoma, might be derived from slgM+, D+/-, CD25+/-, CD5+/-, ALPase-, CD10- and CD11c- lymphocytes present in the mantle zone and primary lymph follicles. Other types of lowgrade B cell neoplasms that were examined had different tumor cell markersfor ig, CD5, CD10, CD11c, a higher PCNA/c rate, and prominent dendritic cells and histiocytic reaction when compared with those of ML, cc (mc)." @default.
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• W2024252318 date "1993-05-01" @default.
• W2024252318 modified "2023-09-25" @default.
• W2024252318 title "Clinicopathologic, enzyme and hisotchemical studies of centrocytic (mantle cell) lymphoma: Comparison with other types of low-grade B cell lymphoma bases on the updated Kiel classification" @default.
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• W2024252318 doi "https://doi.org/10.1111/j.1440-1827.1993.tb01139.x" @default.
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