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- W2024252388 abstract "Respiratory illness due to M. pnewnoniae is common in school age children (peak age 9 yrs.) but rare in infants, a consistent epideraiologic finding which never has been explained adequately. Monitoring of respiratory tract microflora in 50 infants and young children attending the Frank Porter Graham Day Care Center (DCC) yielded 15 isolations of M. pnewroniae from 1968-1973. These infections occurred in the fall and early winter of each year and coincided with identification of this agent in children with lower respiratory disease seen in a local pediatric practice. Frequent medical evaluation revealed only mild rhinitis and cough in half the DCC subjects. Infected children ranged in age from 2 months to 8 years. Diagnostic serologic rises (complement fixing and growth inhibiting antibody), occurred in all but one culture-positive child, as well as in several with negative cultures. Titers tended to wane rapidly and 3 children became reinfected after 3 yrs. In vitro stimulation of peripheral lymphocytes with M. pneumoniae was performed on all infected children during the last year of the study. Antigen reactive cells were detected frequently only in children over 6 yrs. of age. These findings suggest that recurrent unsuspected infection with M. pneumoniae occurs during infancy and early childhood and that pneumonic disease, common in school-aged children, is an expression of increasing host immune response to the organism." @default.
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- W2024252388 date "1974-04-01" @default.
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- W2024252388 title "NEW INSIGHT ON MYCOPLASMA PNEUMONIAE INFECTIONS IN EARLY CHILDHOOD" @default.
- W2024252388 doi "https://doi.org/10.1203/00006450-197404000-00505" @default.
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