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- W2024253060 abstract "Autologous brain cell transplantation might be useful for repairing lesions and restoring function of the central nervous system. We have demonstrated that adult monkey brain cells, obtained from cortical biopsy and kept in culture for a few weeks, exhibit neural progenitor characteristics that make them useful for brain repair. Following MPTP treatment, primates were dopamine depleted but asymptomatic. Autologous cultured cells were reimplanted into the right caudate nucleus of the donor monkey. Four months after reimplantation, histological analysis by stereology and TH immunolabeling showed that the reimplanted cells successfully survived, bilaterally migrated in the whole striatum, and seemed to have a neuroprotection effect over time. These results may add a new strategy to the field of brain neuroprotection or regeneration and could possibly lead to future clinical applications." @default.
- W2024253060 created "2016-06-24" @default.
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- W2024253060 date "2009-07-01" @default.
- W2024253060 modified "2023-09-27" @default.
- W2024253060 title "Primate Adult Brain Cell Autotransplantation, a Pilot Study in Asymptomatic MPTP-Treated Monkeys" @default.
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- W2024253060 doi "https://doi.org/10.3727/096368909x470847" @default.
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