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• W2024253493 abstract "Background: T lymphocytes play a crucial role in the pathogenesis of inflammatory bowel disease. Achieving stable T-cell lines, rather than continuous bleeding of patients, is desirable in order to dissect their implication in the disease. Methods: Long-lasting T-cell lines from patients with Crohn disease and ulcerative colitis and from healthy volunteers have been obtained by transformation of T lymphocytes using the lymphotropic Herpesvirus saimiri. Lines were subjected to phenotypic and functional analyses, and the results compared with freshly isolated peripheral blood mononuclear cells. Results: Fresh cells revealed only minor differences between patients and controls, with regard to phenotype and proliferative capacity. In contrast, the use of T-cell lines showed that cells from Crohn disease patients, but not ulcerative colitis patients, over-responded to several membrane or cytoplasmic stimuli when compared to control T-cell lines. Thus, higher responses were found when stimulated with αCD3 and IL2, αCD3 and αCD28, IL2 alone, phorbol esters (PMA) and αCD3 and, finally, PMA and αCD2 (P < 0.05 in all instances). Further, lines from patients with Crohn disease responded more vigorously to αCD3 and αCD28 or αCD3 and PMA when compared to ulcerative colitis (P < 0.05 in both instances). Conclusions: The data obtained with these lines suggest that T cells from patients with Crohn disease differ in vivo in their proliferative capacity, as compared with those from ulcerative colitis patients, a finding that may reflect the clear Th-1 phenotype found in the former and absent in the latter." @default.
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• W2024253493 date "2004-01-01" @default.
• W2024253493 modified "2023-10-01" @default.
• W2024253493 title "Higher proliferative capacity of T lymphocytes from patients with Crohn disease than from ulcerative colitis is disclosed by use of Herpesvirus saimiri-transformed T-cell lines" @default.
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• W2024253493 doi "https://doi.org/10.1080/00365520410008015" @default.
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