Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024254540> ?p ?o ?g. }
- W2024254540 endingPage "548" @default.
- W2024254540 startingPage "541" @default.
- W2024254540 abstract "Scar formation, caused by the abnormal expression and accumulation of collagen molecules accompanying the expression of heat shock protein 47 (Hsp47), a collagen-specific molecular chaperone, is a serious problem after surgery in the postnate, whereas in the fetus, the wound heals without scarring. In this study, we compared the expression patterns of Hsp47 and type I and type III collagens induced by TGF-β1 between fetal and neonatal fibroblasts in the primary cultures of rat tongues. In the neonate, high level expressions of both Hsp47 and collagen mRNAs and proteins were observed to be induced by TGF-β1, but not in the fetus. We performed a reporter assay using pLUC 5.5 (III), which carried the enhancer/promoter region of the mouse Hsp47 gene, to compare promoter/reporter activity. In the neonate, high promoter/ reporter activity in fibroblasts treated with TGF-β1 was observed, but was unchanged in the fetus. Thus, the expression of Hsp47 is enhanced by TGF-β1 in the neonate but not in the fetus. This different Hsp47 expression pattern between the fetus and neonate appears to be attributed to the different transcriptional regulation of the gene. Elucidation of the regulatory mechanism of Hsp47 production in developmental processes may provide a therapeutic modality for the scarless healing of postnatal wounds." @default.
- W2024254540 created "2016-06-24" @default.
- W2024254540 creator A5002351553 @default.
- W2024254540 creator A5044810717 @default.
- W2024254540 creator A5047345380 @default.
- W2024254540 creator A5072879091 @default.
- W2024254540 date "2002-01-01" @default.
- W2024254540 modified "2023-09-25" @default.
- W2024254540 title "Expression of Hsp47 in Fibroblasts Derived from Fetal and Neonatal Rat Tongues." @default.
- W2024254540 cites W142081883 @default.
- W2024254540 cites W1563167655 @default.
- W2024254540 cites W1592253612 @default.
- W2024254540 cites W1747761114 @default.
- W2024254540 cites W1893483893 @default.
- W2024254540 cites W1964824573 @default.
- W2024254540 cites W1996289117 @default.
- W2024254540 cites W2002736874 @default.
- W2024254540 cites W2004422966 @default.
- W2024254540 cites W2012008369 @default.
- W2024254540 cites W2014671876 @default.
- W2024254540 cites W2020334137 @default.
- W2024254540 cites W2029310602 @default.
- W2024254540 cites W2035185167 @default.
- W2024254540 cites W2038555542 @default.
- W2024254540 cites W2043884900 @default.
- W2024254540 cites W2054365806 @default.
- W2024254540 cites W2055701307 @default.
- W2024254540 cites W2057790206 @default.
- W2024254540 cites W2066272540 @default.
- W2024254540 cites W2069836942 @default.
- W2024254540 cites W2071176654 @default.
- W2024254540 cites W2075155923 @default.
- W2024254540 cites W2077563008 @default.
- W2024254540 cites W2083566893 @default.
- W2024254540 cites W2085394534 @default.
- W2024254540 cites W2088901734 @default.
- W2024254540 cites W2089448437 @default.
- W2024254540 cites W2091462193 @default.
- W2024254540 cites W2096280264 @default.
- W2024254540 cites W2097449478 @default.
- W2024254540 cites W2099952448 @default.
- W2024254540 cites W2100298490 @default.
- W2024254540 cites W2100837269 @default.
- W2024254540 cites W2104276835 @default.
- W2024254540 cites W2129262390 @default.
- W2024254540 cites W2136244950 @default.
- W2024254540 cites W2154222857 @default.
- W2024254540 cites W2159004702 @default.
- W2024254540 cites W2161794048 @default.
- W2024254540 cites W2413266459 @default.
- W2024254540 doi "https://doi.org/10.2330/joralbiosci1965.44.541" @default.
- W2024254540 hasPublicationYear "2002" @default.
- W2024254540 type Work @default.
- W2024254540 sameAs 2024254540 @default.
- W2024254540 citedByCount "1" @default.
- W2024254540 crossrefType "journal-article" @default.
- W2024254540 hasAuthorship W2024254540A5002351553 @default.
- W2024254540 hasAuthorship W2024254540A5044810717 @default.
- W2024254540 hasAuthorship W2024254540A5047345380 @default.
- W2024254540 hasAuthorship W2024254540A5072879091 @default.
- W2024254540 hasBestOaLocation W20242545401 @default.
- W2024254540 hasConcept C104317684 @default.
- W2024254540 hasConcept C111936080 @default.
- W2024254540 hasConcept C142724271 @default.
- W2024254540 hasConcept C150194340 @default.
- W2024254540 hasConcept C153911025 @default.
- W2024254540 hasConcept C161733203 @default.
- W2024254540 hasConcept C165864922 @default.
- W2024254540 hasConcept C172680121 @default.
- W2024254540 hasConcept C203014093 @default.
- W2024254540 hasConcept C2779234561 @default.
- W2024254540 hasConcept C2780269544 @default.
- W2024254540 hasConcept C54355233 @default.
- W2024254540 hasConcept C71924100 @default.
- W2024254540 hasConcept C86803240 @default.
- W2024254540 hasConcept C95444343 @default.
- W2024254540 hasConceptScore W2024254540C104317684 @default.
- W2024254540 hasConceptScore W2024254540C111936080 @default.
- W2024254540 hasConceptScore W2024254540C142724271 @default.
- W2024254540 hasConceptScore W2024254540C150194340 @default.
- W2024254540 hasConceptScore W2024254540C153911025 @default.
- W2024254540 hasConceptScore W2024254540C161733203 @default.
- W2024254540 hasConceptScore W2024254540C165864922 @default.
- W2024254540 hasConceptScore W2024254540C172680121 @default.
- W2024254540 hasConceptScore W2024254540C203014093 @default.
- W2024254540 hasConceptScore W2024254540C2779234561 @default.
- W2024254540 hasConceptScore W2024254540C2780269544 @default.
- W2024254540 hasConceptScore W2024254540C54355233 @default.
- W2024254540 hasConceptScore W2024254540C71924100 @default.
- W2024254540 hasConceptScore W2024254540C86803240 @default.
- W2024254540 hasConceptScore W2024254540C95444343 @default.
- W2024254540 hasIssue "6" @default.
- W2024254540 hasLocation W20242545401 @default.
- W2024254540 hasOpenAccess W2024254540 @default.
- W2024254540 hasPrimaryLocation W20242545401 @default.
- W2024254540 hasRelatedWork W1976451392 @default.
- W2024254540 hasRelatedWork W1990040373 @default.
- W2024254540 hasRelatedWork W2013459239 @default.