Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024255433> ?p ?o ?g. }
- W2024255433 endingPage "1386" @default.
- W2024255433 startingPage "1376" @default.
- W2024255433 abstract "Between January 11, 1991 and January 8, 1992, 104 patients with previously untreated, invasive, primitive breast carcinoma were admitted to the authors' hospital.For each patient, flow cytometry DNA analyses on frozen samples and on immunohistochemical staining were performed, including Ki-67, cyclin A, p53, and p21(waf1) (p21), with assessment of the percentages of positive nuclei were assessed. Correlations with classic clinicopathologic data and survival (overall, metastasis free, or recurrence free) and a multivariate analysis were performed.After a multivariate analysis according to a Cox model that was stratified by age, tumor size, tumor grade, lymph node status, and receptor status, among the factors studied, the presence of p21 was the unique remaining prognostic factor for patients with invasive breast carcinoma. Because of the lack of a correlation between p21 and proliferative factors (Ki-67, S-phase, and cyclin A), the authors combined p21 with those markers and found that, for the different combinations, after statistical analysis, only p21 combined with S-phase or with cyclin A and lymph node status were salient survival prognostic factors.Immunohistochemical study of proteins involved in the cell cycle and assessment of proliferative activity using flow cytometric DNA analysis aided the authors in singling out correlations of cyclin A and S-phase, along with p21, with metastasis free survival and overall survival in patients with invasive breast carcinoma. These promising results will require confirmation in a larger series of patients." @default.
- W2024255433 created "2016-06-24" @default.
- W2024255433 creator A5015981897 @default.
- W2024255433 creator A5024649146 @default.
- W2024255433 creator A5027832488 @default.
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- W2024255433 creator A5048930740 @default.
- W2024255433 creator A5050349063 @default.
- W2024255433 creator A5064102980 @default.
- W2024255433 date "2003-03-03" @default.
- W2024255433 modified "2023-10-18" @default.
- W2024255433 title "Flow cytometry and quantitative immunohistochemical study of cell cycle regulation proteins in invasive breast carcinoma" @default.
- W2024255433 cites W119536604 @default.
- W2024255433 cites W1963692923 @default.
- W2024255433 cites W1963955893 @default.
- W2024255433 cites W1970393845 @default.
- W2024255433 cites W1975619340 @default.
- W2024255433 cites W1977147812 @default.
- W2024255433 cites W1980094148 @default.
- W2024255433 cites W1983597466 @default.
- W2024255433 cites W1984671863 @default.
- W2024255433 cites W1984975924 @default.
- W2024255433 cites W1986193653 @default.
- W2024255433 cites W1987622162 @default.
- W2024255433 cites W1988679772 @default.
- W2024255433 cites W1992082979 @default.
- W2024255433 cites W1993326038 @default.
- W2024255433 cites W1998204845 @default.
- W2024255433 cites W1999862667 @default.
- W2024255433 cites W2001516292 @default.
- W2024255433 cites W2003339483 @default.
- W2024255433 cites W2005630333 @default.
- W2024255433 cites W2005819738 @default.
- W2024255433 cites W2007927993 @default.
- W2024255433 cites W2009031924 @default.
- W2024255433 cites W2011727075 @default.
- W2024255433 cites W2011923462 @default.
- W2024255433 cites W2013377097 @default.
- W2024255433 cites W2014067978 @default.
- W2024255433 cites W2017819822 @default.
- W2024255433 cites W2018385269 @default.
- W2024255433 cites W2020698008 @default.
- W2024255433 cites W2020948029 @default.
- W2024255433 cites W2022485504 @default.
- W2024255433 cites W2026362225 @default.
- W2024255433 cites W2027286465 @default.
- W2024255433 cites W2028461591 @default.
- W2024255433 cites W2029912336 @default.
- W2024255433 cites W2031749650 @default.
- W2024255433 cites W2032442585 @default.
- W2024255433 cites W2034315888 @default.
- W2024255433 cites W2034453521 @default.
- W2024255433 cites W2035978064 @default.
- W2024255433 cites W2036755756 @default.
- W2024255433 cites W2037539424 @default.
- W2024255433 cites W2039976295 @default.
- W2024255433 cites W2041499243 @default.
- W2024255433 cites W2042350842 @default.
- W2024255433 cites W2043620199 @default.
- W2024255433 cites W2048216287 @default.
- W2024255433 cites W2048632014 @default.
- W2024255433 cites W2051267694 @default.
- W2024255433 cites W2051544472 @default.
- W2024255433 cites W2052394372 @default.
- W2024255433 cites W2052565867 @default.
- W2024255433 cites W2055482904 @default.
- W2024255433 cites W2055687655 @default.
- W2024255433 cites W2055961110 @default.
- W2024255433 cites W2060469293 @default.
- W2024255433 cites W2060623604 @default.
- W2024255433 cites W2062329553 @default.
- W2024255433 cites W2062393705 @default.
- W2024255433 cites W2063511222 @default.
- W2024255433 cites W2067902038 @default.
- W2024255433 cites W2071086152 @default.
- W2024255433 cites W2072319696 @default.
- W2024255433 cites W2074010664 @default.
- W2024255433 cites W2074072651 @default.
- W2024255433 cites W2076044934 @default.
- W2024255433 cites W2076365549 @default.
- W2024255433 cites W2085339143 @default.
- W2024255433 cites W2087109753 @default.
- W2024255433 cites W2089002270 @default.
- W2024255433 cites W2092480212 @default.
- W2024255433 cites W2094251908 @default.
- W2024255433 cites W2098567881 @default.
- W2024255433 cites W2119683486 @default.
- W2024255433 cites W2128678633 @default.
- W2024255433 cites W2140961023 @default.
- W2024255433 cites W2142368338 @default.
- W2024255433 cites W2148269604 @default.
- W2024255433 cites W2154094995 @default.
- W2024255433 cites W2162975775 @default.
- W2024255433 cites W2253846115 @default.
- W2024255433 cites W2270349763 @default.
- W2024255433 cites W2303500246 @default.
- W2024255433 cites W2313409493 @default.
- W2024255433 cites W2328982008 @default.