FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024255965> ?p ?o ?g. }

• W2024255965 endingPage "128" @default.
• W2024255965 startingPage "123" @default.
• W2024255965 abstract "Our study is the first to demonstrate the ability to generate iPS cells from a mouse model of Pompe disease. Initially, mouse tail tip fibroblasts were harvested from male, 8-week-old (GAA) knockout mice, and three reprogramming factors (Oct3/4, Sox2 and Klf4) were transfected into the isolated donor cells using a retroviral vector. These iPS cells also showed decreased levels of GAA enzymatic activity and strong positive staining with periodic acid-Schiff (indicating the accumulation of glycogen) and acid phosphatase (lysosomal activation marker). Pompe-iPS cells were differentiated into skeletal muscle cells in Matrigel®-coated plates. Spindle-shaped skeletal muscle cells were successfully generated from Pompe-iPS cells and showed spontaneous contraction and positive staining with the myosin heavy chain antibody. Electron microscopic analysis of the skeletal muscle cells showed typical morphological features, including Z-bands, I-bands, A-bands and H-bands, which were visible in wild-type and Pompe cells. Furthermore, Pompe skeletal muscle cells accumulated massive glycogen in lysosomes. This study indicates that the iPS and skeletal muscle cells generated in this study could also be a useful disease model for studies investigating the pathogenesis and treatment of skeletal muscle in Pompe disease." @default.
• W2024255965 created "2016-06-24" @default.
• W2024255965 creator A5002357141 @default.
• W2024255965 creator A5003162347 @default.
• W2024255965 creator A5006928387 @default.
• W2024255965 creator A5007438879 @default.
• W2024255965 creator A5025137772 @default.
• W2024255965 creator A5030021970 @default.
• W2024255965 creator A5034883605 @default.
• W2024255965 creator A5041696451 @default.
• W2024255965 creator A5042601597 @default.
• W2024255965 creator A5048174806 @default.
• W2024255965 creator A5051862367 @default.
• W2024255965 creator A5053448001 @default.
• W2024255965 creator A5083428025 @default.
• W2024255965 creator A5088937824 @default.
• W2024255965 date "2011-09-01" @default.
• W2024255965 modified "2023-09-23" @default.
• W2024255965 title "Generation of induced pluripotent stem (iPS) cells derived from a murine model of Pompe disease and differentiation of Pompe-iPS cells into skeletal muscle cells" @default.
• W2024255965 cites W1978173381 @default.
• W2024255965 cites W1984182083 @default.
• W2024255965 cites W1987902896 @default.
• W2024255965 cites W1988793208 @default.
• W2024255965 cites W2019926561 @default.
• W2024255965 cites W2026911195 @default.
• W2024255965 cites W2047627643 @default.
• W2024255965 cites W2054521968 @default.
• W2024255965 cites W2055655054 @default.
• W2024255965 cites W2068592712 @default.
• W2024255965 cites W2075039427 @default.
• W2024255965 cites W2088654061 @default.
• W2024255965 cites W2093722439 @default.
• W2024255965 cites W2098130155 @default.
• W2024255965 cites W2099289539 @default.
• W2024255965 cites W2125987139 @default.
• W2024255965 cites W2127215106 @default.
• W2024255965 cites W2138421186 @default.
• W2024255965 cites W2145986851 @default.
• W2024255965 cites W2157467277 @default.
• W2024255965 cites W2159490726 @default.
• W2024255965 cites W2160203801 @default.
• W2024255965 cites W2161841050 @default.
• W2024255965 cites W2329756551 @default.
• W2024255965 doi "https://doi.org/10.1016/j.ymgme.2011.05.020" @default.
• W2024255965 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21703893" @default.
• W2024255965 hasPublicationYear "2011" @default.
• W2024255965 type Work @default.
• W2024255965 sameAs 2024255965 @default.
• W2024255965 citedByCount "27" @default.
• W2024255965 countsByYear W20242559652012 @default.
• W2024255965 countsByYear W20242559652013 @default.
• W2024255965 countsByYear W20242559652014 @default.
• W2024255965 countsByYear W20242559652015 @default.
• W2024255965 countsByYear W20242559652016 @default.
• W2024255965 countsByYear W20242559652017 @default.
• W2024255965 countsByYear W20242559652018 @default.
• W2024255965 countsByYear W20242559652019 @default.
• W2024255965 countsByYear W20242559652020 @default.
• W2024255965 countsByYear W20242559652021 @default.
• W2024255965 countsByYear W20242559652022 @default.
• W2024255965 crossrefType "journal-article" @default.
• W2024255965 hasAuthorship W2024255965A5002357141 @default.
• W2024255965 hasAuthorship W2024255965A5003162347 @default.
• W2024255965 hasAuthorship W2024255965A5006928387 @default.
• W2024255965 hasAuthorship W2024255965A5007438879 @default.
• W2024255965 hasAuthorship W2024255965A5025137772 @default.
• W2024255965 hasAuthorship W2024255965A5030021970 @default.
• W2024255965 hasAuthorship W2024255965A5034883605 @default.
• W2024255965 hasAuthorship W2024255965A5041696451 @default.
• W2024255965 hasAuthorship W2024255965A5042601597 @default.
• W2024255965 hasAuthorship W2024255965A5048174806 @default.
• W2024255965 hasAuthorship W2024255965A5051862367 @default.
• W2024255965 hasAuthorship W2024255965A5053448001 @default.
• W2024255965 hasAuthorship W2024255965A5083428025 @default.
• W2024255965 hasAuthorship W2024255965A5088937824 @default.
• W2024255965 hasConcept C104317684 @default.
• W2024255965 hasConcept C107459253 @default.
• W2024255965 hasConcept C134018914 @default.
• W2024255965 hasConcept C142724271 @default.
• W2024255965 hasConcept C145103041 @default.
• W2024255965 hasConcept C1491633281 @default.
• W2024255965 hasConcept C153911025 @default.
• W2024255965 hasConcept C185592680 @default.
• W2024255965 hasConcept C207200792 @default.
• W2024255965 hasConcept C2776735236 @default.
• W2024255965 hasConcept C2777933648 @default.
• W2024255965 hasConcept C2778265714 @default.
• W2024255965 hasConcept C2778608917 @default.
• W2024255965 hasConcept C2779134260 @default.
• W2024255965 hasConcept C2779959927 @default.
• W2024255965 hasConcept C2779969927 @default.
• W2024255965 hasConcept C54009773 @default.
• W2024255965 hasConcept C54355233 @default.
• W2024255965 hasConcept C55493867 @default.
• W2024255965 hasConcept C6997183 @default.
• W2024255965 hasConcept C71924100 @default.
• W2024255965 hasConcept C81885089 @default.
• W2024255965 hasConcept C86803240 @default.

• next