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- W2024256040 abstract "The pathophysiology of primary dystonia is thought to involve dysfunction of the basal ganglia cortico-striatal-thalamo-cortical motor circuits. In the past, emphasis was placed on the role of the basal ganglia in controlling movements; in more recent times, however, it has also become clear that they play an important part in sensory functions. Thus, although the most dramatic symptoms in dystonia seem to be motor in nature, marked somatosensory perceptual deficits are also present in this disease. Recent behavioural studies have shown that these sensory functions are compromised in patients with several forms of primary dystonia. Changes have been found in temporal discrimination and integration of sensory signals, spatial discrimination of tactile stimuli, perception of the vibration-induced illusion of movement, and other illusions (the rubber hand and Aristotele’s illusion). The search for abnormalities of sensation was stimulated by the observation in a primate model of dystonia that showed enlarged and overlapped receptive fields of the hand in the S1 after stereotypic movements of the hand. Abnormal representation in S1 of the fingers involved in dystonia characterized by smaller distance between the fingers has been also observed in patients affected by focal hand dystonia using neuroimaging studies. One possible pathophysiological mechanisms for these abnormalities could be a loss of inhibition at multiple levels of the somatosensory system, as documented by somatosensory evoked potentials studies. Consequently, abnormal processing of the somatosensory input may lead to an inefficient sensorimotor integration, thus contributing to the generation of dystonic movements. This talk focuses on sensory function abnormalities described in primary dystonia using different approaches and techniques and their possible role in the pathophysiology of this syndrome, highlighting potential implications for innovative therapeutic strategies to aid functional recovery." @default.
- W2024256040 created "2016-06-24" @default.
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- W2024256040 date "2015-03-01" @default.
- W2024256040 modified "2023-09-27" @default.
- W2024256040 title "11. Sensory functions in primary dystonia" @default.
- W2024256040 doi "https://doi.org/10.1016/j.clinph.2014.10.170" @default.
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