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- W2024257340 abstract "Background . Treatment of patients with a biochemical recurrence (BCR) of prostate cancer (PCa) is generally difficult and without valid treatment options. Since 2004 we have been developing therapeutic possibilities for these patients. Methods . We retrospectively analyzed a cohort of 41 patients with a BCR of PCa and a mean followup of<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mn>40.3</mml:mn><mml:mo>±</mml:mo><mml:mn>20.8</mml:mn></mml:math>months. Group 1 (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>10</mml:mn></mml:math>): salvage radical prostatectomy (sRP) with SePLND (salvage extended pelvic lymph nodes dissection) (initial treatment: combined brachytherapy). Group 2 (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>22</mml:mn></mml:math>): SePLND (initial treatment: radical prostatectomy (RP)). Group 3 (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>9</mml:mn></mml:math>): SePLND (initial treatment: RP and adjuvant radiation therapy (RT)). We observed PSA, PSA-velocity, localization of LNs and LNs+, BCR-free period, and BR (biochemical response). Results . Group 1: 60% with BCR-freedom (mean 27.2 months). Group 2: 63.6% with BCR-freedom (mean 17.5 months). Group 3: 33.3% with BCR-freedom (mean 17.6 months). In total, BCR-freedom was observed in 23 of 41 patients (56.1%) after salvage surgery. 75.6% of all patients showed a BR. 765 LNs were removed and 14.8% of these were LN+. Conclusions . The BCR-free period and BR are comparable in all three groups. Sensibility to ADT can be reestablished and prolonged as a result of SePLND. Multicenter studies are needed for a reliable output." @default.
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- W2024257340 date "2014-01-01" @default.
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- W2024257340 title "Extended Salvage Pelvic Lymph Node Dissection in Patients with Recurrent Prostate Cancer" @default.
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- W2024257340 doi "https://doi.org/10.1155/2014/321619" @default.
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