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- W2024257345 endingPage "193" @default.
- W2024257345 startingPage "182" @default.
- W2024257345 abstract "Abstract: Hyperpolarization-activated cation nonselective cyclic nucleotide-gated (HCN) channels mediate pacemaker currents that control basic rhythmic processes including heartbeat. Alterations in HCN channel expression or function have been described in both epilepsy and cardiac arrhythmias. Recent evidence suggests that pacemaker currents may also play an important role in ectopic neuronal activity that manifests as neuropathic pain. Pacemaker currents are subject to endogenous regulation by cyclic nucleotides, pH and perhaps phosphorylation. In addition, a number of neuromodulators with known roles in pain affect current density and kinetics. The pharmacology of a number of drugs that are commonly used to treat neuropathic pain includes effects on pacemaker currents. Altered pacemaker currents in injured tissues may be an important mechanism underlying neuropathic pain, and drugs that modulate these currents may offer new therapeutic options." @default.
- W2024257345 created "2016-06-24" @default.
- W2024257345 creator A5002053999 @default.
- W2024257345 creator A5013915280 @default.
- W2024257345 creator A5072777316 @default.
- W2024257345 date "2004-09-01" @default.
- W2024257345 modified "2023-10-16" @default.
- W2024257345 title "The Role of Pacemaker Currents in Neuropathic Pain" @default.
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