Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024257569> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2024257569 abstract "Purpose: To obtain probability distributions of various DNA damage types as a function of the incident electron kinetic energy. Methods: Using Geant4-DNA electron ionization cross-sections, we calculated path length distributions for electrons of energies between 10 eV and 1 MeV, defined as the length between two subsequent interactions. These path lengths were then convolved with probability distributions for the creation of same-strand damage, opposite-strand damage, clustered damage, isolated damage, and same DNA strand target damage. These probability distributions of DNA damage were obtained by a Monte Carlo routine calculating probabilities of interaction in DNA targets inside a nucleosome geometrical model. Results represent the probability of a secondary electron, initially created inside a DNA strand target, of undergoing its next interaction: (1) in the opposite strand (DSB), (2) in the same strand (SSB+), (3) in either the opposite or same-strand (clustered), (4) in the same DNA target (multiple-hit) or (5) more than 10 base pairs away (isolated). Results: Electrons with kinetic energy between 50 and 250 eV have a maximal probability of creating DSB, SSB+, clustered damage and multiple-hits in the same target The probabilities for these damage patterns have values of 2.5%, 4.3%, 6.7% and 5.4%, respectively. Isolated damage ismore » most probable between 700 eV to 900 eV with a probability of 0.2%. Conclusion: We obtained DNA damage probability distributions as a function of electron incident energy. We showed that electrons with kinetic energies between 50 and 250 eV have the highest probability of producing complex forms of DNA damage (DSB, SSB+). We also showed that a double ionization within the same DNA target is the most frequent outcome occurring 5% of the time. It is expected that electron slowing down spectra can be convolved with our formalism to calculate source specific DNA damage patterns. Research grants from governments of Canada and Quebec. PP acknowledges partial support by the CREATE Medical Physics Research Training Network grant of the Natural Sciences and Engineering Research Council (Grant number: 432290)« less" @default.
- W2024257569 created "2016-06-24" @default.
- W2024257569 creator A5008289966 @default.
- W2024257569 creator A5010597773 @default.
- W2024257569 creator A5034012305 @default.
- W2024257569 date "2014-05-29" @default.
- W2024257569 modified "2023-09-27" @default.
- W2024257569 title "WE-E-BRE-11: New Method to Simulate DNA Damage Using Ionization Cross-Sections and a Geometrical Nucleosome Model" @default.
- W2024257569 doi "https://doi.org/10.1118/1.4889440" @default.
- W2024257569 hasPublicationYear "2014" @default.
- W2024257569 type Work @default.
- W2024257569 sameAs 2024257569 @default.
- W2024257569 citedByCount "0" @default.
- W2024257569 crossrefType "journal-article" @default.
- W2024257569 hasAuthorship W2024257569A5008289966 @default.
- W2024257569 hasAuthorship W2024257569A5010597773 @default.
- W2024257569 hasAuthorship W2024257569A5034012305 @default.
- W2024257569 hasConcept C105795698 @default.
- W2024257569 hasConcept C121332964 @default.
- W2024257569 hasConcept C135889238 @default.
- W2024257569 hasConcept C143425029 @default.
- W2024257569 hasConcept C145148216 @default.
- W2024257569 hasConcept C147120987 @default.
- W2024257569 hasConcept C149441793 @default.
- W2024257569 hasConcept C184779094 @default.
- W2024257569 hasConcept C185544564 @default.
- W2024257569 hasConcept C185592680 @default.
- W2024257569 hasConcept C19499675 @default.
- W2024257569 hasConcept C198291218 @default.
- W2024257569 hasConcept C33923547 @default.
- W2024257569 hasConcept C34667332 @default.
- W2024257569 hasConcept C552990157 @default.
- W2024257569 hasConcept C55493867 @default.
- W2024257569 hasConcept C62520636 @default.
- W2024257569 hasConceptScore W2024257569C105795698 @default.
- W2024257569 hasConceptScore W2024257569C121332964 @default.
- W2024257569 hasConceptScore W2024257569C135889238 @default.
- W2024257569 hasConceptScore W2024257569C143425029 @default.
- W2024257569 hasConceptScore W2024257569C145148216 @default.
- W2024257569 hasConceptScore W2024257569C147120987 @default.
- W2024257569 hasConceptScore W2024257569C149441793 @default.
- W2024257569 hasConceptScore W2024257569C184779094 @default.
- W2024257569 hasConceptScore W2024257569C185544564 @default.
- W2024257569 hasConceptScore W2024257569C185592680 @default.
- W2024257569 hasConceptScore W2024257569C19499675 @default.
- W2024257569 hasConceptScore W2024257569C198291218 @default.
- W2024257569 hasConceptScore W2024257569C33923547 @default.
- W2024257569 hasConceptScore W2024257569C34667332 @default.
- W2024257569 hasConceptScore W2024257569C552990157 @default.
- W2024257569 hasConceptScore W2024257569C55493867 @default.
- W2024257569 hasConceptScore W2024257569C62520636 @default.
- W2024257569 hasLocation W20242575691 @default.
- W2024257569 hasOpenAccess W2024257569 @default.
- W2024257569 hasPrimaryLocation W20242575691 @default.
- W2024257569 hasRelatedWork W108815439 @default.
- W2024257569 hasRelatedWork W1679381177 @default.
- W2024257569 hasRelatedWork W1986562272 @default.
- W2024257569 hasRelatedWork W1991906289 @default.
- W2024257569 hasRelatedWork W1999588951 @default.
- W2024257569 hasRelatedWork W2021584290 @default.
- W2024257569 hasRelatedWork W2025380995 @default.
- W2024257569 hasRelatedWork W2030144124 @default.
- W2024257569 hasRelatedWork W2031841858 @default.
- W2024257569 hasRelatedWork W2048470431 @default.
- W2024257569 hasRelatedWork W2048532294 @default.
- W2024257569 hasRelatedWork W2050160484 @default.
- W2024257569 hasRelatedWork W2081284309 @default.
- W2024257569 hasRelatedWork W2113762659 @default.
- W2024257569 hasRelatedWork W2115211387 @default.
- W2024257569 hasRelatedWork W2159983928 @default.
- W2024257569 hasRelatedWork W2212880761 @default.
- W2024257569 hasRelatedWork W2323717385 @default.
- W2024257569 hasRelatedWork W2329821041 @default.
- W2024257569 hasRelatedWork W2612197075 @default.
- W2024257569 isParatext "false" @default.
- W2024257569 isRetracted "false" @default.
- W2024257569 magId "2024257569" @default.
- W2024257569 workType "article" @default.