Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024257919> ?p ?o ?g. }
- W2024257919 endingPage "259" @default.
- W2024257919 startingPage "249" @default.
- W2024257919 abstract "The porcine immune system is unique in the expression of CD4+CD8+ (double-positive, DP) lymphocytes. These cells have been associated with immunological memory due to their gradual increase with age, the expression of memory phenotype and their ability to respond to recall viral antigen. This work analyzes the biological function of CD4+CD8− and CD4+CD8+ lymphocytes in the immune response to porcine rubulavirus (PRv). CD4+CD8− cells isolated from pigs 3 weeks after infection with porcine rubulavirus proliferated in response to homologous virus and generated lymphoblasts which were predominantly of the CD4+CD8+ phenotype, whereas stimulation with mitogen induced proliferation but did not switch the phenotype. CD4+CD8− lymphocytes isolated after 10 weeks of infection proliferated in response to phytohemagglutinin (PHA) but did not proliferate in response to homologous virus and did not change their phenotype, whereas CD4+CD8+ lymphocytes proliferated in response to PHA and to viral antigen. The cytokine profile of both lymphocyte populations showed the presence of IL-2 and IL-10 transcripts, quantitation demonstrated that CD4+CD8+ cells expressed mainly IL-10, whereas CD4+CD8− lymphocytes expressed primarily IL-2. Our results show that CD4+CD8− lymphocytes in the early phase of porcine rubulavirus infection can be converted to double-positive cells expressing IL-10 in an antigen-dependent manner, and that CD4+CD8− T-cells late in infection do not acquire CD8." @default.
- W2024257919 created "2016-06-24" @default.
- W2024257919 creator A5011435230 @default.
- W2024257919 creator A5022355595 @default.
- W2024257919 creator A5033775394 @default.
- W2024257919 creator A5046350479 @default.
- W2024257919 creator A5077159822 @default.
- W2024257919 creator A5091110827 @default.
- W2024257919 date "2001-05-01" @default.
- W2024257919 modified "2023-09-30" @default.
- W2024257919 title "Comparative evaluation of the CD4+CD8+ and CD4+CD8− lymphocytes in the immune response to porcine rubulavirus" @default.
- W2024257919 cites W1516915945 @default.
- W2024257919 cites W1625897096 @default.
- W2024257919 cites W1657567895 @default.
- W2024257919 cites W1671840178 @default.
- W2024257919 cites W1853319271 @default.
- W2024257919 cites W1942668068 @default.
- W2024257919 cites W1968102829 @default.
- W2024257919 cites W1974543461 @default.
- W2024257919 cites W1984035854 @default.
- W2024257919 cites W1988086743 @default.
- W2024257919 cites W1998985749 @default.
- W2024257919 cites W2007978997 @default.
- W2024257919 cites W2008779901 @default.
- W2024257919 cites W2018157303 @default.
- W2024257919 cites W2018868619 @default.
- W2024257919 cites W2025282235 @default.
- W2024257919 cites W2036287577 @default.
- W2024257919 cites W2037551106 @default.
- W2024257919 cites W2049121617 @default.
- W2024257919 cites W2052254275 @default.
- W2024257919 cites W2053155150 @default.
- W2024257919 cites W2064155252 @default.
- W2024257919 cites W2070998543 @default.
- W2024257919 cites W2079716079 @default.
- W2024257919 cites W2084990572 @default.
- W2024257919 cites W2149764521 @default.
- W2024257919 cites W2174557896 @default.
- W2024257919 cites W2177116430 @default.
- W2024257919 cites W2208092455 @default.
- W2024257919 cites W4231581694 @default.
- W2024257919 cites W4293247451 @default.
- W2024257919 doi "https://doi.org/10.1016/s0165-2427(01)00259-8" @default.
- W2024257919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11389959" @default.
- W2024257919 hasPublicationYear "2001" @default.
- W2024257919 type Work @default.
- W2024257919 sameAs 2024257919 @default.
- W2024257919 citedByCount "33" @default.
- W2024257919 countsByYear W20242579192012 @default.
- W2024257919 countsByYear W20242579192013 @default.
- W2024257919 countsByYear W20242579192014 @default.
- W2024257919 countsByYear W20242579192015 @default.
- W2024257919 countsByYear W20242579192016 @default.
- W2024257919 countsByYear W20242579192017 @default.
- W2024257919 countsByYear W20242579192019 @default.
- W2024257919 countsByYear W20242579192021 @default.
- W2024257919 countsByYear W20242579192023 @default.
- W2024257919 crossrefType "journal-article" @default.
- W2024257919 hasAuthorship W2024257919A5011435230 @default.
- W2024257919 hasAuthorship W2024257919A5022355595 @default.
- W2024257919 hasAuthorship W2024257919A5033775394 @default.
- W2024257919 hasAuthorship W2024257919A5046350479 @default.
- W2024257919 hasAuthorship W2024257919A5077159822 @default.
- W2024257919 hasAuthorship W2024257919A5091110827 @default.
- W2024257919 hasConcept C113842279 @default.
- W2024257919 hasConcept C147483822 @default.
- W2024257919 hasConcept C153911025 @default.
- W2024257919 hasConcept C154317977 @default.
- W2024257919 hasConcept C159047783 @default.
- W2024257919 hasConcept C167672396 @default.
- W2024257919 hasConcept C202751555 @default.
- W2024257919 hasConcept C203014093 @default.
- W2024257919 hasConcept C2992881475 @default.
- W2024257919 hasConcept C54355233 @default.
- W2024257919 hasConcept C81885089 @default.
- W2024257919 hasConcept C86803240 @default.
- W2024257919 hasConcept C8891405 @default.
- W2024257919 hasConceptScore W2024257919C113842279 @default.
- W2024257919 hasConceptScore W2024257919C147483822 @default.
- W2024257919 hasConceptScore W2024257919C153911025 @default.
- W2024257919 hasConceptScore W2024257919C154317977 @default.
- W2024257919 hasConceptScore W2024257919C159047783 @default.
- W2024257919 hasConceptScore W2024257919C167672396 @default.
- W2024257919 hasConceptScore W2024257919C202751555 @default.
- W2024257919 hasConceptScore W2024257919C203014093 @default.
- W2024257919 hasConceptScore W2024257919C2992881475 @default.
- W2024257919 hasConceptScore W2024257919C54355233 @default.
- W2024257919 hasConceptScore W2024257919C81885089 @default.
- W2024257919 hasConceptScore W2024257919C86803240 @default.
- W2024257919 hasConceptScore W2024257919C8891405 @default.
- W2024257919 hasIssue "3-4" @default.
- W2024257919 hasLocation W20242579191 @default.
- W2024257919 hasLocation W20242579192 @default.
- W2024257919 hasOpenAccess W2024257919 @default.
- W2024257919 hasPrimaryLocation W20242579191 @default.
- W2024257919 hasRelatedWork W1495829907 @default.
- W2024257919 hasRelatedWork W2008949385 @default.
- W2024257919 hasRelatedWork W2018916009 @default.