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• W2024258529 abstract "Lack of access to quality biospecimens and associated health data is a major roadblock to clinical and translational research. While major advances have been achieved in the emerging field of personalised medicine, significantly more research is required to understand the genomic and proteomic factors 1 underlying many diseases including cancer. The establishment of large repositories of annotated biospecimens is considered by many the only way to meet the current and future demands of translational medicine. We are addressing the deficiency in biospecimen availability through establishment of the Health Science Alliance (HSA) Biobank, an institutional biobank implemented within South Eastern Sydney Local Health District (SESLHD) hospitals and the University of New South Wales (UNSW) Australia. As an institutional biobank, the processes of HSA biobank consent, biospecimen and data collection are integrated within the hospital patient care pathway. In this way, the biobank is sustained by ongoing collaboration between patients, clinicians, nurses, hospital support staff, researchers and pathologists. The HSA Biobank began collection in April 2012 of solid organ tissues, bone marrow, matched blood or buccal swab, and associated health data, with participant consent. The intersections between the patient care pathway in the hospital and the processes of the HSA Biobank are outlined in Fig. 1. Our aim is to have biobank processes embedded across all hospital practices, while ensuring minimal impact to staff workloads and patient care workflows. The ultimate goal is that biobanking becomes a routine part of patient care. In two years of operation, this set-up has provided over 2650 biobank specimens from over 1400 consenting participants who have had a recent diagnosis of cancer. Clinicians and researchers see value in institutional biobanking. However, hospital-wide uptake of HSA Biobank practices, as well as researcher use of biobank resources, relies on the implementation of collection processes that are appropriate, routine and trustworthy. Hence, diagnostic pathology plays a central role in the collection of tissue and data for the HSA Biobank. In the HSA model it is pathologists and haematologists, rather than surgeons, who are responsible for the allocation of tissues and bone marrow to the biobank. The expertise and discretion of specialist pathologists ensures that the diagnostic integrity of tissue is maintained and that the optimal quality and quantity of banked specimens is achieved (Table 1). While in some cases, biobank tissue is allocated by pathologists without prior knowledge of HSA Biobank consent status, the long-term storage of tissue and receipt of patient health data by the HSA Biobank only occurs when consent to do so is obtained from participants. Any tissue for which participant consent is" @default.
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• W2024258529 date "2015-01-01" @default.
• W2024258529 modified "2023-09-27" @default.
• W2024258529 title "Institutional biobanking: an integral part of contemporary pathology practice" @default.
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• W2024258529 doi "https://doi.org/10.1097/pat.0000000000000185" @default.
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