FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024259316> ?p ?o ?g. }

• W2024259316 endingPage "1085.e6" @default.
• W2024259316 startingPage "1075" @default.
• W2024259316 abstract "Although inhaled glucocorticoids are the mainstays of asthma treatment, they are poorly effective at treating and preventing virus-induced asthma exacerbations. The major viruses precipitating asthma exacerbations are rhinoviruses.We sought to evaluate whether rhinovirus infection interferes with the mechanisms of action of glucocorticoids.Cultured primary human bronchial or transformed (A549) respiratory epithelial cells were infected with rhinovirus 16 (RV-16) before dexamethasone exposure. Glucocorticoid receptor (GR) α nuclear translocation, glucocorticoid response element (GRE) binding, and transactivation/transrepression functional readouts were evaluated by using immunocytochemistry, Western blotting, DNA binding assays, real-time quantitative PCR, coimmunoprecipitation, and ELISA techniques. Specific inhibitors of c-Jun N-terminal kinase (JNK) and of IκB kinase (IKK) were used to investigate the involvement of intracellular signaling pathways.RV-16 infection impaired dexamethasone-dependent (1) inhibition of IL-1β-induced CXCL8 release, (2) induction of mitogen-activated protein kinase phosphatase 1 gene expression, and (3) binding of GR to GREs in airway epithelial cells. This was associated with impaired GRα nuclear translocation, as assessed by means of both immunochemistry (54.0% ± 6.8% vs 24.7% ± 3.8% GR-positive nuclei after 10 nmol/L dexamethasone treatment in sham- or RV-16-infected cells, respectively; P < .01) and Western blotting. RV-16 infection induced nuclear factor κB activation and GRα phosphorylation, which were prevented by inhibitors of IKK2 and JNK, respectively. In rhinovirus-infected cells the combination of JNK and IKK2 inhibitors totally restored dexamethasone suppression of CXCL8 release, induction of mitogen-activated protein kinase phosphatase 1 gene expression, and GRα nuclear translocation.RV-16 infection of human airway epithelium induces glucocorticoid resistance. Inhibition of RV-16-induced JNK and nuclear factor κB activation fully reversed rhinovirus impairment of both GRα nuclear translocation and the transactivation/transrepression activities of glucocorticoids." @default.
• W2024259316 created "2016-06-24" @default.
• W2024259316 creator A5011323669 @default.
• W2024259316 creator A5013475705 @default.
• W2024259316 creator A5013873491 @default.
• W2024259316 creator A5016161340 @default.
• W2024259316 creator A5029256576 @default.
• W2024259316 creator A5030258071 @default.
• W2024259316 creator A5040751152 @default.
• W2024259316 creator A5050163445 @default.
• W2024259316 creator A5055881015 @default.
• W2024259316 creator A5060075204 @default.
• W2024259316 creator A5063587197 @default.
• W2024259316 date "2013-11-01" @default.
• W2024259316 modified "2023-10-05" @default.
• W2024259316 title "Rhinovirus infection causes steroid resistance in airway epithelium through nuclear factor κB and c-Jun N-terminal kinase activation" @default.
• W2024259316 cites W1568518323 @default.
• W2024259316 cites W1597584551 @default.
• W2024259316 cites W1759028523 @default.
• W2024259316 cites W1820270771 @default.
• W2024259316 cites W1964779747 @default.
• W2024259316 cites W1967441187 @default.
• W2024259316 cites W1970703972 @default.
• W2024259316 cites W1971627390 @default.
• W2024259316 cites W1974904073 @default.
• W2024259316 cites W1976548850 @default.
• W2024259316 cites W1981703255 @default.
• W2024259316 cites W1983955745 @default.
• W2024259316 cites W1986896480 @default.
• W2024259316 cites W1989016734 @default.
• W2024259316 cites W1996335217 @default.
• W2024259316 cites W1998805154 @default.
• W2024259316 cites W2003189930 @default.
• W2024259316 cites W2007736853 @default.
• W2024259316 cites W2018963759 @default.
• W2024259316 cites W2024625607 @default.
• W2024259316 cites W2024688475 @default.
• W2024259316 cites W2038099088 @default.
• W2024259316 cites W2038229245 @default.
• W2024259316 cites W2046822015 @default.
• W2024259316 cites W2050317906 @default.
• W2024259316 cites W2064229941 @default.
• W2024259316 cites W2066202970 @default.
• W2024259316 cites W2069845084 @default.
• W2024259316 cites W2072099958 @default.
• W2024259316 cites W2073463392 @default.
• W2024259316 cites W2091754459 @default.
• W2024259316 cites W2099297532 @default.
• W2024259316 cites W2104829952 @default.
• W2024259316 cites W2105746658 @default.
• W2024259316 cites W2108236415 @default.
• W2024259316 cites W2110040793 @default.
• W2024259316 cites W2112433605 @default.
• W2024259316 cites W2117904842 @default.
• W2024259316 cites W2132065245 @default.
• W2024259316 cites W2133106781 @default.
• W2024259316 cites W2142805807 @default.
• W2024259316 cites W2145906341 @default.
• W2024259316 cites W2150459577 @default.
• W2024259316 cites W2150691073 @default.
• W2024259316 cites W2153426162 @default.
• W2024259316 cites W2155687796 @default.
• W2024259316 cites W2158275128 @default.
• W2024259316 cites W2159602556 @default.
• W2024259316 cites W2160443208 @default.
• W2024259316 cites W2162764250 @default.
• W2024259316 cites W2166084959 @default.
• W2024259316 cites W4249212674 @default.
• W2024259316 doi "https://doi.org/10.1016/j.jaci.2013.05.028" @default.
• W2024259316 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23871663" @default.
• W2024259316 hasPublicationYear "2013" @default.
• W2024259316 type Work @default.
• W2024259316 sameAs 2024259316 @default.
• W2024259316 citedByCount "78" @default.
• W2024259316 countsByYear W20242593162014 @default.
• W2024259316 countsByYear W20242593162015 @default.
• W2024259316 countsByYear W20242593162016 @default.
• W2024259316 countsByYear W20242593162017 @default.
• W2024259316 countsByYear W20242593162018 @default.
• W2024259316 countsByYear W20242593162019 @default.
• W2024259316 countsByYear W20242593162020 @default.
• W2024259316 countsByYear W20242593162021 @default.
• W2024259316 countsByYear W20242593162022 @default.
• W2024259316 countsByYear W20242593162023 @default.
• W2024259316 crossrefType "journal-article" @default.
• W2024259316 hasAuthorship W2024259316A5011323669 @default.
• W2024259316 hasAuthorship W2024259316A5013475705 @default.
• W2024259316 hasAuthorship W2024259316A5013873491 @default.
• W2024259316 hasAuthorship W2024259316A5016161340 @default.
• W2024259316 hasAuthorship W2024259316A5029256576 @default.
• W2024259316 hasAuthorship W2024259316A5030258071 @default.
• W2024259316 hasAuthorship W2024259316A5040751152 @default.
• W2024259316 hasAuthorship W2024259316A5050163445 @default.
• W2024259316 hasAuthorship W2024259316A5055881015 @default.
• W2024259316 hasAuthorship W2024259316A5060075204 @default.
• W2024259316 hasAuthorship W2024259316A5063587197 @default.
• W2024259316 hasBestOaLocation W20242593162 @default.
• W2024259316 hasConcept C104317684 @default.

• next