FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024259561> ?p ?o ?g. }

• W2024259561 endingPage "302" @default.
• W2024259561 startingPage "299" @default.
• W2024259561 abstract "Integrase inhibitors are recently prescribed to multi-class drug resistant HIV-1 patients in Hong Kong. Unlike pol gene, there are no FDA-approved genotypic resistance tests available for int. Limited studies compared the performance between an in-house and commercial integrase genotyping system. Information on baseline polymorphisms was also insufficient in our region.To compare integrase genotyping data obtained from an in-house and ViroSeq™ Integra48 assay, and to illustrate integrase polymorphisms on HIV-1 B and non-B subtypes in Hong Kong.A total of 283 HIV-1 patients were recruited during 2006-2012 in Hong Kong. All samples were genotyped by an in-house assay for pol and int separately, and 46 of them were further genotyped by ViroSeq™ Integra48. Polymorphisms and resistance mutations were analyzed by Stanford HIV Drug Resistance Database.The included patients were mainly infected by HIV-1 subtype B (38.9%) and CRF01_AE (43.1%), followed by CRF07_BC (5.3%), C (3.9%), CRF02_AG (2.8%), D (1.4%), CRF08_BC (1.1%) or others (3.5%). Of 46 samples genotyped by ViroSeq™ and the in-house assays, all major and minor resistance mutations were concordant. Integrase major resistance mutations were identified in two CRF01_AE raltegravir-treated patients. Integrase minor resistance mutations were observed in subtypes B and CRF01_AE.With 25% of the commercial cost, the in-house integrase genotyping assay managed to regenerate over 96% concordant results as good as the RUO ViroSeq™ assay. Further investigations are required to understand the effect on integrase minor mutations, which are present in many subtype B and CRF01_AE samples." @default.
• W2024259561 created "2016-06-24" @default.
• W2024259561 creator A5004148540 @default.
• W2024259561 creator A5013814203 @default.
• W2024259561 creator A5024887159 @default.
• W2024259561 creator A5032778667 @default.
• W2024259561 creator A5043267247 @default.
• W2024259561 creator A5046973356 @default.
• W2024259561 creator A5073177761 @default.
• W2024259561 creator A5074941879 @default.
• W2024259561 date "2013-09-01" @default.
• W2024259561 modified "2023-10-14" @default.
• W2024259561 title "Performance comparison of an in-house integrase genotyping assay versus the ViroSeq™ Integra48, and study of HIV-1 integrase polymorphisms in Hong Kong" @default.
• W2024259561 cites W1967390610 @default.
• W2024259561 cites W1983837630 @default.
• W2024259561 cites W2010585539 @default.
• W2024259561 cites W2018545343 @default.
• W2024259561 cites W2041921162 @default.
• W2024259561 cites W2046412323 @default.
• W2024259561 cites W2067264613 @default.
• W2024259561 cites W2073738512 @default.
• W2024259561 cites W2076696614 @default.
• W2024259561 cites W2106866317 @default.
• W2024259561 cites W2108829333 @default.
• W2024259561 cites W2114822477 @default.
• W2024259561 cites W2124600882 @default.
• W2024259561 cites W2128260028 @default.
• W2024259561 cites W2133323045 @default.
• W2024259561 cites W2133355061 @default.
• W2024259561 cites W2135041676 @default.
• W2024259561 cites W2135417699 @default.
• W2024259561 cites W2137646827 @default.
• W2024259561 cites W2140333504 @default.
• W2024259561 cites W2154164013 @default.
• W2024259561 cites W2156933277 @default.
• W2024259561 cites W2168350753 @default.
• W2024259561 cites W2407029875 @default.
• W2024259561 cites W2258524519 @default.
• W2024259561 doi "https://doi.org/10.1016/j.jcv.2013.06.040" @default.
• W2024259561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23886504" @default.
• W2024259561 hasPublicationYear "2013" @default.
• W2024259561 type Work @default.
• W2024259561 sameAs 2024259561 @default.
• W2024259561 citedByCount "7" @default.
• W2024259561 countsByYear W20242595612015 @default.
• W2024259561 countsByYear W20242595612019 @default.
• W2024259561 countsByYear W20242595612021 @default.
• W2024259561 countsByYear W20242595612023 @default.
• W2024259561 crossrefType "journal-article" @default.
• W2024259561 hasAuthorship W2024259561A5004148540 @default.
• W2024259561 hasAuthorship W2024259561A5013814203 @default.
• W2024259561 hasAuthorship W2024259561A5024887159 @default.
• W2024259561 hasAuthorship W2024259561A5032778667 @default.
• W2024259561 hasAuthorship W2024259561A5043267247 @default.
• W2024259561 hasAuthorship W2024259561A5046973356 @default.
• W2024259561 hasAuthorship W2024259561A5073177761 @default.
• W2024259561 hasAuthorship W2024259561A5074941879 @default.
• W2024259561 hasConcept C104317684 @default.
• W2024259561 hasConcept C114851261 @default.
• W2024259561 hasConcept C135763542 @default.
• W2024259561 hasConcept C142462285 @default.
• W2024259561 hasConcept C14430832 @default.
• W2024259561 hasConcept C159047783 @default.
• W2024259561 hasConcept C2777302000 @default.
• W2024259561 hasConcept C2780404665 @default.
• W2024259561 hasConcept C2993143319 @default.
• W2024259561 hasConcept C3013748606 @default.
• W2024259561 hasConcept C31467283 @default.
• W2024259561 hasConcept C54355233 @default.
• W2024259561 hasConcept C86803240 @default.
• W2024259561 hasConceptScore W2024259561C104317684 @default.
• W2024259561 hasConceptScore W2024259561C114851261 @default.
• W2024259561 hasConceptScore W2024259561C135763542 @default.
• W2024259561 hasConceptScore W2024259561C142462285 @default.
• W2024259561 hasConceptScore W2024259561C14430832 @default.
• W2024259561 hasConceptScore W2024259561C159047783 @default.
• W2024259561 hasConceptScore W2024259561C2777302000 @default.
• W2024259561 hasConceptScore W2024259561C2780404665 @default.
• W2024259561 hasConceptScore W2024259561C2993143319 @default.
• W2024259561 hasConceptScore W2024259561C3013748606 @default.
• W2024259561 hasConceptScore W2024259561C31467283 @default.
• W2024259561 hasConceptScore W2024259561C54355233 @default.
• W2024259561 hasConceptScore W2024259561C86803240 @default.
• W2024259561 hasIssue "1" @default.
• W2024259561 hasLocation W20242595611 @default.
• W2024259561 hasLocation W20242595612 @default.
• W2024259561 hasOpenAccess W2024259561 @default.
• W2024259561 hasPrimaryLocation W20242595611 @default.
• W2024259561 hasRelatedWork W1551896540 @default.
• W2024259561 hasRelatedWork W2012847512 @default.
• W2024259561 hasRelatedWork W2024259561 @default.
• W2024259561 hasRelatedWork W2041921162 @default.
• W2024259561 hasRelatedWork W2069736986 @default.
• W2024259561 hasRelatedWork W2155028449 @default.
• W2024259561 hasRelatedWork W2156551413 @default.
• W2024259561 hasRelatedWork W3009214008 @default.
• W2024259561 hasRelatedWork W3037811918 @default.
• W2024259561 hasRelatedWork W3134235852 @default.

• next