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- W2024262427 abstract "We asked whether regenerating hindlimb motor axons would innervate inappropriate hindlimb regions if competition from appropriate innervation were prevented. The three ventral roots that innervate the hindlimb in the bullfrog (Rana catesbeiana) tadpole were transected, and the two more rostral roots were ligated to prevent regeneration. The most caudal root, which primarily supplies more distal limb musculature in unoperated tadpoles, was left free to regnerate. The specificity of regeneration was assessed by retrogradely labeling spinal motoneurons with HRP placed in the ventral thigh, a region that receives most of its innervation from the ligated roots. Despite the lack of competition from appropriate innervation, the regenerating root did not provide substantial innervation to proximal limb musculature. The same result was obtained in tadpoles operated upon at stages when regeneration of motor axons is specific and in tadpoles at stages when regenerating motor axons do not reinnervate their appropriate targets (Farel and Bemelmans, 1986), although the mechanisms in each case are likely different." @default.
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- W2024262427 date "1989-03-01" @default.
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- W2024262427 title "Regenerative specificity of motor axons when reinnervation is partially suppressed" @default.
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- W2024262427 doi "https://doi.org/10.1002/neu.480200203" @default.
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