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- W20242661 endingPage "392" @default.
- W20242661 startingPage "377" @default.
- W20242661 abstract "This chapter describes individual treatment modalities, with focus on their efficacy and safety for prevention and treatment of osteoporosis. Estrogen deficiency accompanying the menopause is now a generally accepted contributor to the pathogenesis of postmenopausal osteoporosis. The most plausible therapy to prevent consequences of estrogen deficiency is to administer hormone replacement therapy (HRT), which is a combination of estrogen-progestogen therapy. Combination of HRT with androgens increases the benefits, particularly at the hip. Estrogen analogs comprise of selective estrogen receptor modulators. The subsequent development of tamoxifen has revolutionized the therapeutic approach. A new strategy has been developed to exploit the target site for the beneficial actions of estrogen. Bisphosphonates represent a class of drugs developed for use in various diseases of the skeleton, teeth, and calcium metabolism. Long-term treatment with calcitonin not only inhibits osteoclast activity, but also decreases the number of osteoclasts. Anabolic steroids have been used for many years for the treatment of osteoporosis. Parathyroid hormone is one of the calcium regulating hormones whose physiologic effect is to stimulate bone resorption. Strontium ranelate decreases bone resorption and increases bone formation, promoting a lasting positive calcium and consequent increases in bone mass." @default.
- W20242661 created "2016-06-24" @default.
- W20242661 creator A5005612011 @default.
- W20242661 creator A5037947964 @default.
- W20242661 date "2007-01-01" @default.
- W20242661 modified "2023-10-18" @default.
- W20242661 title "Treatment of Osteoporosis" @default.
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- W20242661 doi "https://doi.org/10.1016/b978-012369443-0/50036-3" @default.
- W20242661 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3306525" @default.