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• W2024268433 endingPage "1654" @default.
• W2024268433 startingPage "1638" @default.
• W2024268433 abstract "Most of what is known about the pathogenesis of inflammatory bowel disease (IBD) pertains to complex interplay between host genetics, immunity, and environmental factors. Epigenetic modifications play pivotal roles in intestinal immunity and mucosal homeostasis as well as mediating gene-environment interactions. In this article, we provide a historical account of epigenetic research either directly related or pertinent to the pathogenesis and management of IBD. We further collate emerging evidence supporting roles for epigenetic mechanisms in relevant aspects of IBD biology, including deregulated immunity, host-pathogen recognition and mucosal integrity. Finally, we highlight key epigenetic mechanisms that link chronic inflammation to specific IBD comorbidities, including colitis-associated cancer and discuss their potential utility as novel biomarkers or pharmacologic targets in IBD therapy." @default.
• W2024268433 created "2016-06-24" @default.
• W2024268433 creator A5060843864 @default.
• W2024268433 creator A5083009182 @default.
• W2024268433 date "2014-09-01" @default.
• W2024268433 modified "2023-09-26" @default.
• W2024268433 title "Linking Immunity, Epigenetics, and Cancer in Inflammatory Bowel Disease" @default.
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