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• W2024269229 abstract "1. Glucuronidation of clofibric acid, the pharmacologically active form of the hypolipidemic drug clofibrate was investigated in a human population, either in vitro with liver homogenates from biopsies, or after ingestion of the drug and determination of the urinary metabolite. No difference in the glucuronidation rate according to age of the patients was observed. Bilirubin but not clofibric acid glucuronidation was significantly higher in women (106% increase), when expressed per gram of tissue. 2. The excretion of clofibryl glucuronide in women who took oral contraceptives was significantly enhanced by 25%. 3. In female rats, treatment with the contraceptive agent norethindrone also stimulated by 48% the formation of clofibrylglucuronide in liver microsomes." @default.
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• W2024269229 date "1991-01-01" @default.
• W2024269229 modified "2023-09-25" @default.
• W2024269229 title "Oral contraceptives stimulate the excretion of clofibric acid glucuronide in women and female rats" @default.
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• W2024269229 doi "https://doi.org/10.1016/0306-3623(91)90470-q" @default.
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