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• W2024269871 endingPage "1168" @default.
• W2024269871 startingPage "1163" @default.
• W2024269871 abstract "Bleeding and climacteric symptoms were recorded in two groups of postmenopausal women receiving either continuous combined estradiol and norethisterone acetate or estradiol and cyproterone acetate. Out of a sample of 99 postmenopausal women aged 45 to 54 years, 86 completed a 2-year, double-blind, placebo-controlled study. Comparison of the bleeding patterns in the two groups revealed a statistically significant difference: More women in the estradiol-cyproterone acetate group experienced bleeding and for a longer duration. Thirteen women in the estradiol-norethisterone acetate group were amenorrheic, compared with two in the other group. The Kupperman index score in both groups declined to about 30% to 40% of initial values (p less than 0.001). The hot flushes in both treatment groups decreased to a highly significant degree (p less than 0.001), to a value below 20% of baseline values. We conclude that a continuous combination of estrogen and progestogen can produce amenorrhea and symptomatic relief. However, the progestogen components seem to differ in their ability to control bleeding." @default.
• W2024269871 created "2016-06-24" @default.
• W2024269871 creator A5005612011 @default.
• W2024269871 creator A5067291968 @default.
• W2024269871 creator A5086071936 @default.
• W2024269871 date "1991-05-01" @default.
• W2024269871 modified "2023-10-18" @default.
• W2024269871 title "Bleeding patterns during continuous combined estrogen-progestogen therapy" @default.
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• W2024269871 doi "https://doi.org/10.1016/0002-9378(91)90677-j" @default.
• W2024269871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1827947" @default.
• W2024269871 hasPublicationYear "1991" @default.
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