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- W2024271337 endingPage "S28" @default.
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- W2024271337 abstract "The confluence of rapid scientific advancements especially in protein engineering and recombinant technology, unmet medical needs, and commercial incentives have led to the development of the next generation of therapeutic proteins. Bispecific antibody constructs are one of the novel strategies that is being pursued, combining the ability to bind simultaneously to two distinct targets and the advantages of purpose-designed and optimized antibody-based scaffolds. Their pharmacokinetic and pharmacodynamic properties, including their immunogenic potential, are closely related to their structural features and ability to interact with disposition mechanisms of immunoglobulin molecules. Catumaxomab and blinatumomab are bispecific constructs that are approved for clinical use and have provided clinical pharmacology data for this novel class of therapeutics. This knowledgebase on the clinical behavior of bispecific therapeutic proteins is poised to rapidly evolve over the next few years with many development programs having entered the clinical development stage." @default.
- W2024271337 created "2016-06-24" @default.
- W2024271337 creator A5006059698 @default.
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- W2024271337 date "2015-02-23" @default.
- W2024271337 modified "2023-09-29" @default.
- W2024271337 title "Clinical pharmacology of bispecific antibody constructs" @default.
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- W2024271337 doi "https://doi.org/10.1002/jcph.445" @default.
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