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• W2024275653 abstract "<h3>Objectives</h3> To analyze the association between cigarette smoking and biochemical recurrence (BCR) after radical prostatectomy among men from the Shared Equal Access Regional Cancer Hospital (SEARCH) cohort. <h3>Methods</h3> We performed a retrospective analysis of 1267 subjects from the SEARCH cohort treated from 1998 to 2008 with smoking status available from the preoperative notes. A comparison of the baseline patient and disease characteristics between the current smokers and nonsmokers (past and never smokers combined) was performed using the chi-square and rank sum tests. The univariate and multivariate associations between smoking status and BCR-free survival were analyzed using Kaplan-Meier plots, the log-rank test, and Cox proportional hazard models. <h3>Results</h3> Of the 1267 patients, 408 (32%) were active smokers and 859 (68%) were nonsmokers at surgery. The current smokers were younger (<i>P</i> <.001), more likely to be black (<i>P</i> <.001), and had a lower body mass index (<i>P</i> <.001), a greater percentage of positive biopsy cores (<i>P</i> = .039), a greater preoperative prostate-specific antigen level (<i>P</i> = .003), more extracapsular extension (<i>P</i> = .003) and seminal vesicle invasion (<i>P</i> = .029), and lower prostate volumes (<i>P</i> = .002). On univariate analysis, smokers had a risk of BCR similar to that of nonsmokers (hazard ratio 1.19, <i>P</i> = .129). On multivariate analysis, smoking was associated with an increased risk of BCR when adjusted for body mass index only (hazard ratio 1.37, <i>P</i> = .008). However, after adjustment for multiple preoperative characteristics, the association was attenuated and no longer statistically significant (hazard ratio 1.12, <i>P</i> = .325). After additional adjustment for postoperative features, such as tumor grade and stage, smoking was unrelated to the risk of BCR (hazard ratio 0.91, <i>P</i> = .502). <h3>Conclusions</h3> Among patients undergoing radical prostatectomy in the SEARCH cohort, cigarette smoking was associated with slightly more advanced disease but a similar risk of BCR." @default.
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• W2024275653 date "2010-11-01" @default.
• W2024275653 modified "2023-09-27" @default.
• W2024275653 title "Association of Cigarette Smoking With Interval to Biochemical Recurrence After Radical Prostatectomy: Results from the SEARCH Database" @default.
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• W2024275653 doi "https://doi.org/10.1016/j.urology.2010.01.066" @default.
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