FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024277989> ?p ?o ?g. }

• W2024277989 endingPage "72" @default.
• W2024277989 startingPage "61" @default.
• W2024277989 abstract "The induction of 2F5- and 4E10-like antibodies broadly neutralising HIV-1 and targeting the membrane external proximal region (MPER) of the transmembrane envelope protein gp41 would be a major advancement for the development of a preventive HIV-1 vaccine, but successful attempts remain rare. Recent studies demonstrated that broadly reactive antibodies develop relatively late during infection and after intensive affinity maturation. Therefore, a prolonged antigen delivery might be beneficial to induce them. Replicating foamy viruses which are characterised by apathogenic but persistent infection could represent suitable carrier viruses for this purpose. In order to develop such a system, we modified the accessory foamy virus Bet protein to contain the MPER of gp41, or the MPER linked to the stabilising fusion peptide proximal region of gp41 and analysed here the antigenic and immunogenic properties of such hybrid proteins. The antigens, expressed and purified to homogeneity, were recognised by the monoclonal antibodies 2F5 and 4E10 with nanomolar affinities and induced high levels of antibodies specific to gp41 after immunisation of rats. The antisera also bound to virus particles attached to infected cells, and peptide-based epitope mapping showed that they recognised the 2F5 epitope. Although no HIV-1 neutralising activity was observed, the presented data demonstrate that using the foamy virus Bet for HIV-1 epitope delivery is successfully applicable. Together with the attractive potential for sustained antigen expression after transfer to replicating virus, these results should therefore provide a first basis for the development of chimeric foamy viruses as novel HIV-1 vaccine vectors." @default.
• W2024277989 created "2016-06-24" @default.
• W2024277989 creator A5045648972 @default.
• W2024277989 creator A5078813913 @default.
• W2024277989 creator A5079303125 @default.
• W2024277989 creator A5084359200 @default.
• W2024277989 date "2013-02-26" @default.
• W2024277989 modified "2023-09-26" @default.
• W2024277989 title "Immunisation with foamy virus Bet fusion proteins as novel strategy for HIV-1 epitope delivery" @default.
• W2024277989 cites W1519704494 @default.
• W2024277989 cites W1528872128 @default.
• W2024277989 cites W1619678312 @default.
• W2024277989 cites W1635348995 @default.
• W2024277989 cites W166593606 @default.
• W2024277989 cites W1966616903 @default.
• W2024277989 cites W1968249040 @default.
• W2024277989 cites W1969156908 @default.
• W2024277989 cites W1970277994 @default.
• W2024277989 cites W1971147540 @default.
• W2024277989 cites W1976982929 @default.
• W2024277989 cites W1980322325 @default.
• W2024277989 cites W1987003026 @default.
• W2024277989 cites W1988257424 @default.
• W2024277989 cites W1989567487 @default.
• W2024277989 cites W1990621039 @default.
• W2024277989 cites W1992866551 @default.
• W2024277989 cites W1993072141 @default.
• W2024277989 cites W1998987175 @default.
• W2024277989 cites W2002193732 @default.
• W2024277989 cites W2002389148 @default.
• W2024277989 cites W2003051762 @default.
• W2024277989 cites W2003847421 @default.
• W2024277989 cites W2008717353 @default.
• W2024277989 cites W2009960465 @default.
• W2024277989 cites W2023434411 @default.
• W2024277989 cites W2023749753 @default.
• W2024277989 cites W2024444579 @default.
• W2024277989 cites W2028499952 @default.
• W2024277989 cites W2029499132 @default.
• W2024277989 cites W2032238176 @default.
• W2024277989 cites W2033645653 @default.
• W2024277989 cites W2034942909 @default.
• W2024277989 cites W2045439785 @default.
• W2024277989 cites W2047921952 @default.
• W2024277989 cites W2050372002 @default.
• W2024277989 cites W2052667955 @default.
• W2024277989 cites W2054224584 @default.
• W2024277989 cites W2054392131 @default.
• W2024277989 cites W2055264619 @default.
• W2024277989 cites W2055885674 @default.
• W2024277989 cites W2058632331 @default.
• W2024277989 cites W2060127667 @default.
• W2024277989 cites W2064612669 @default.
• W2024277989 cites W2067372868 @default.
• W2024277989 cites W2069542935 @default.
• W2024277989 cites W2070220357 @default.
• W2024277989 cites W2072925709 @default.
• W2024277989 cites W2074867344 @default.
• W2024277989 cites W2075345074 @default.
• W2024277989 cites W2078913377 @default.
• W2024277989 cites W2079440821 @default.
• W2024277989 cites W2083094268 @default.
• W2024277989 cites W2083171477 @default.
• W2024277989 cites W2085048408 @default.
• W2024277989 cites W2085762846 @default.
• W2024277989 cites W2091209917 @default.
• W2024277989 cites W2102548388 @default.
• W2024277989 cites W2104784743 @default.
• W2024277989 cites W2105364254 @default.
• W2024277989 cites W2105903892 @default.
• W2024277989 cites W2109541209 @default.
• W2024277989 cites W2120463956 @default.
• W2024277989 cites W2121182046 @default.
• W2024277989 cites W2127072493 @default.
• W2024277989 cites W2129181852 @default.
• W2024277989 cites W2131674674 @default.
• W2024277989 cites W2152440860 @default.
• W2024277989 cites W2154575731 @default.
• W2024277989 cites W2162546635 @default.
• W2024277989 cites W2171536421 @default.
• W2024277989 cites W4241040961 @default.
• W2024277989 doi "https://doi.org/10.1007/s12026-013-8387-x" @default.
• W2024277989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23440699" @default.
• W2024277989 hasPublicationYear "2013" @default.
• W2024277989 type Work @default.
• W2024277989 sameAs 2024277989 @default.
• W2024277989 citedByCount "7" @default.
• W2024277989 countsByYear W20242779892012 @default.
• W2024277989 countsByYear W20242779892013 @default.
• W2024277989 countsByYear W20242779892014 @default.
• W2024277989 countsByYear W20242779892015 @default.
• W2024277989 countsByYear W20242779892016 @default.
• W2024277989 countsByYear W20242779892018 @default.
• W2024277989 crossrefType "journal-article" @default.
• W2024277989 hasAuthorship W2024277989A5045648972 @default.
• W2024277989 hasAuthorship W2024277989A5078813913 @default.
• W2024277989 hasAuthorship W2024277989A5079303125 @default.
• W2024277989 hasAuthorship W2024277989A5084359200 @default.

• next