FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024279142> ?p ?o ?g. }

• W2024279142 endingPage "428" @default.
• W2024279142 startingPage "421" @default.
• W2024279142 abstract "Vascular inflammation and lipid deposition are prominent features of atherosclerotic lesion formation. We have shown previously that the dithiol compound alpha-lipoic acid (LA) exerts antiinflammatory effects by inhibiting tumor necrosis factor-alpha- and lipopolysaccharide-induced endothelial and monocyte activation in vitro and lipopolysaccharide-induced acute inflammatory responses in vivo. Here, we investigated whether LA inhibits atherosclerosis in apolipoprotein E-deficient (apoE-/-) and apoE/low-density lipoprotein receptor-deficient mice, 2 well-established animal models of human atherosclerosis.Four-week-old female apoE-/- mice (n=20 per group) or apoE/low-density lipoprotein receptor-deficient mice (n=21 per group) were fed for 10 weeks a Western-type chow diet containing 15% fat and 0.125% cholesterol without or with 0.2% (wt/wt) R,S-LA or a normal chow diet containing 4% fat without or with 0.2% (wt/wt) R-LA, respectively. Supplementation with LA significantly reduced atherosclerotic lesion formation in the aortic sinus of both mouse models by approximately 20% and in the aortic arch and thoracic aorta of apoE-/- and apoE/low-density lipoprotein receptor-deficient mice by approximately 55% and 40%, respectively. This strong antiatherogenic effect of LA was associated with almost 40% less body weight gain and lower serum and very low-density lipoprotein levels of triglycerides but not cholesterol. In addition, LA supplementation reduced aortic expression of adhesion molecules and proinflammatory cytokines and aortic macrophage accumulation. These antiinflammatory effects of LA were more pronounced in the aortic arch and the thoracic aorta than in the aortic sinus, reflecting the corresponding reductions in atherosclerosis.Our study shows that dietary LA supplementation inhibits atherosclerotic lesion formation in 2 mouse models of human atherosclerosis, an inhibition that appears to be due to the antiobesity, antihypertriglyceridemic, and antiinflammatory effects of LA. LA may be a useful adjunct in the prevention and treatment of atherosclerotic vascular diseases." @default.
• W2024279142 created "2016-06-24" @default.
• W2024279142 creator A5020817154 @default.
• W2024279142 creator A5026450314 @default.
• W2024279142 creator A5033471433 @default.
• W2024279142 creator A5033942837 @default.
• W2024279142 creator A5063609079 @default.
• W2024279142 creator A5070619411 @default.
• W2024279142 date "2008-01-22" @default.
• W2024279142 modified "2023-09-23" @default.
• W2024279142 title "Dietary α-Lipoic Acid Supplementation Inhibits Atherosclerotic Lesion Development in Apolipoprotein E–Deficient and Apolipoprotein E/Low-Density Lipoprotein Receptor–Deficient Mice" @default.
• W2024279142 cites W1516434930 @default.
• W2024279142 cites W1577091995 @default.
• W2024279142 cites W1886864374 @default.
• W2024279142 cites W1965696818 @default.
• W2024279142 cites W1988848089 @default.
• W2024279142 cites W1991720779 @default.
• W2024279142 cites W2002582015 @default.
• W2024279142 cites W2015230474 @default.
• W2024279142 cites W2019305546 @default.
• W2024279142 cites W2038537523 @default.
• W2024279142 cites W2046728427 @default.
• W2024279142 cites W2056245899 @default.
• W2024279142 cites W2058626978 @default.
• W2024279142 cites W2066963386 @default.
• W2024279142 cites W2078600320 @default.
• W2024279142 cites W2079268420 @default.
• W2024279142 cites W2083165373 @default.
• W2024279142 cites W2092890519 @default.
• W2024279142 cites W2095279166 @default.
• W2024279142 cites W2095968828 @default.
• W2024279142 cites W2103996548 @default.
• W2024279142 cites W2114952735 @default.
• W2024279142 cites W2117307804 @default.
• W2024279142 cites W2125510262 @default.
• W2024279142 cites W2137598362 @default.
• W2024279142 cites W2165668387 @default.
• W2024279142 cites W2234418224 @default.
• W2024279142 cites W2265892904 @default.
• W2024279142 cites W2324841714 @default.
• W2024279142 cites W2614955500 @default.
• W2024279142 doi "https://doi.org/10.1161/circulationaha.107.725275" @default.
• W2024279142 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18158360" @default.
• W2024279142 hasPublicationYear "2008" @default.
• W2024279142 type Work @default.
• W2024279142 sameAs 2024279142 @default.
• W2024279142 citedByCount "86" @default.
• W2024279142 countsByYear W20242791422012 @default.
• W2024279142 countsByYear W20242791422013 @default.
• W2024279142 countsByYear W20242791422014 @default.
• W2024279142 countsByYear W20242791422015 @default.
• W2024279142 countsByYear W20242791422016 @default.
• W2024279142 countsByYear W20242791422017 @default.
• W2024279142 countsByYear W20242791422018 @default.
• W2024279142 countsByYear W20242791422019 @default.
• W2024279142 countsByYear W20242791422020 @default.
• W2024279142 countsByYear W20242791422021 @default.
• W2024279142 countsByYear W20242791422022 @default.
• W2024279142 countsByYear W20242791422023 @default.
• W2024279142 crossrefType "journal-article" @default.
• W2024279142 hasAuthorship W2024279142A5020817154 @default.
• W2024279142 hasAuthorship W2024279142A5026450314 @default.
• W2024279142 hasAuthorship W2024279142A5033471433 @default.
• W2024279142 hasAuthorship W2024279142A5033942837 @default.
• W2024279142 hasAuthorship W2024279142A5063609079 @default.
• W2024279142 hasAuthorship W2024279142A5070619411 @default.
• W2024279142 hasBestOaLocation W20242791421 @default.
• W2024279142 hasConcept C126322002 @default.
• W2024279142 hasConcept C134018914 @default.
• W2024279142 hasConcept C142724271 @default.
• W2024279142 hasConcept C164027704 @default.
• W2024279142 hasConcept C17991360 @default.
• W2024279142 hasConcept C2776864027 @default.
• W2024279142 hasConcept C2776914184 @default.
• W2024279142 hasConcept C2778163477 @default.
• W2024279142 hasConcept C2779134260 @default.
• W2024279142 hasConcept C2779980429 @default.
• W2024279142 hasConcept C2780072125 @default.
• W2024279142 hasConcept C2780562891 @default.
• W2024279142 hasConcept C2781156865 @default.
• W2024279142 hasConcept C43554185 @default.
• W2024279142 hasConcept C57089818 @default.
• W2024279142 hasConcept C62746215 @default.
• W2024279142 hasConcept C71924100 @default.
• W2024279142 hasConceptScore W2024279142C126322002 @default.
• W2024279142 hasConceptScore W2024279142C134018914 @default.
• W2024279142 hasConceptScore W2024279142C142724271 @default.
• W2024279142 hasConceptScore W2024279142C164027704 @default.
• W2024279142 hasConceptScore W2024279142C17991360 @default.
• W2024279142 hasConceptScore W2024279142C2776864027 @default.
• W2024279142 hasConceptScore W2024279142C2776914184 @default.
• W2024279142 hasConceptScore W2024279142C2778163477 @default.
• W2024279142 hasConceptScore W2024279142C2779134260 @default.
• W2024279142 hasConceptScore W2024279142C2779980429 @default.
• W2024279142 hasConceptScore W2024279142C2780072125 @default.
• W2024279142 hasConceptScore W2024279142C2780562891 @default.
• W2024279142 hasConceptScore W2024279142C2781156865 @default.
• W2024279142 hasConceptScore W2024279142C43554185 @default.

• next