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• W2024281322 startingPage "258" @default.
• W2024281322 abstract "Gastroesophageal reflux disease (GERD) is very common and advances in drug development over recent years have markedly improved GERD management. A wide range of medications are currently used in GERD treatment, including antacids, Gaviscon, sucralfate, histamine-2 receptor antagonists and prokinetics. However, proton pump inhibitors (PPIs) remain the mainstay of treatment for GERD owing to their profound and consistent inhibitory effect on acid secretion. Despite the presence of a wide armamentarium of therapeutic modalities for GERD, many areas of unmet needs remain. Drug development has focused primarily on improving PPI efficacy, reducing the transient lower esophageal sphincter relaxation rate, attenuating esophageal sensitivity and developing esophageal mucosal protectants." @default.
• W2024281322 created "2016-06-24" @default.
• W2024281322 creator A5010191776 @default.
• W2024281322 creator A5022335823 @default.
• W2024281322 date "2011-04-01" @default.
• W2024281322 modified "2023-09-26" @default.
• W2024281322 title "Pharmacological management of GERD: where does it stand now?" @default.
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• W2024281322 doi "https://doi.org/10.1016/j.tips.2011.02.007" @default.
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