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• W2024282621 endingPage "1280" @default.
• W2024282621 startingPage "1276" @default.
• W2024282621 abstract "Naphthoquinones have been studied extensively due to their activity as topoisomerase inhibitors. These enzymes are critical to DNA replication in cells. beta-Lapachone (beta-lap) is an o-naphthoquinone chemically obtained from lapachol. This work results in a toxicological evaluation of beta-lap in Wistar rats observing the following parameters: teratology, histology, hematology and serum biochemistry. The data demonstrate teratogenic action at the doses used, as well as hematological alterations in the total leukocytes, monocytes and segmented. The biochemical data demonstrated an increase in gamma glutamyl transferase, alkaline phosphatase and glutamate pyruvate transaminase levels. Histological study showed significant alterations in the spleen, however, the liver and kidney did not present significant alterations." @default.
• W2024282621 created "2016-06-24" @default.
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• W2024282621 date "2009-09-01" @default.
• W2024282621 modified "2023-09-23" @default.
• W2024282621 title "Toxicological assessment of beta-lapachone on organs from pregnant and non-pregnant rats" @default.
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• W2024282621 doi "https://doi.org/10.1002/ptr.2646" @default.
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• W2024282621 hasPublicationYear "2009" @default.
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