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- W2024283409 abstract "Abstract Insulin secretion from pancreatic β‐cells is a complex process, involving the integration and interaction of multiple external and internal stimuli, in which glucose plays a major role. Understanding the physiology leading to insulin release is a crucial step toward the identification of new targets. In this study, we evaluated the presence of insulinotropic metabolites in Naja kaouthia snake venom. Only one fraction, identified as cardiotoxin‐I (CTX‐I) was able to induce insulin secretion from INS‐1E cells without affecting cell viability and integrity, as assessed by MTT and LDH assays. Interestingly, CTX‐I was also able to stimulate insulin secretion from INS‐1E cells even in the absence of glucose. Although cardiotoxins have been characterized as potent hemolytic agents and vasoconstrictors, CTX‐I was unable to induce direct hemolysis of human erythrocytes or to induce potent vasoconstriction. As such, this newly identified insulin‐releasing toxin will surely enrich the pool of existing tools to study β‐cell physiology or even open a new therapeutic avenue." @default.
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- W2024283409 date "2012-07-16" @default.
- W2024283409 modified "2023-10-17" @default.
- W2024283409 title "Cardiotoxin-I: An Unexpectedly Potent Insulinotropic Agent" @default.
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- W2024283409 doi "https://doi.org/10.1002/cbic.201200081" @default.
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