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• W2024283663 abstract "The effects of third ventricular injections of Ca++, Mg++, Na+ and K+ on feeding, drinking and intraperitoneal (IP) temperature were studied in sheep. The chloride salts were dissolved in synthetic CSF (control) and injected (0.5ml) at a rate of 0.2 ml/min into satiated sheep. Ca++ and Mg++ injections elicited dose dependent feeding responses but Ca++ resulted in greater feeding. Doses as little as 1.5 μmoles/animal of either Ca++ or Mg++ elicited feeding with a latency of about 2 min and lasted for 15 min postinjection. With larger doses, the duration of the feeding response increased but the latency stayed the same. A 20 or 40 μmole dose of K+ elicited a decrease in feed intake. Na+ given at similar doses produced an increase in water consumption without affecting feeding. Injections of either Na+ or K+ 10 min prior to either Ca++ or Mg++ resulted in only normal feeding. K+ inhibited the feeding response to both Ca++ and Mg++ at dose levels lower than the doses of Na+ required (40 vs 550 μmoles). The inhibitory effect of Na+ on Ca++ feeding was overcome by either increasing the dose of Ca++ or decreasing the dose of Na+. Water intake was generally increased after injections of Ca++, Mg++ and Na+. Intraperitoneal temperatures increased after injections of Na+ and Mg++ but remained unchanged after injections of Ca++, K+ or synthetic CSF. We conclude that the CNS mechanisms for the control of feeding in sheep are sensitive to changes in the ionic environment of brain tissue, probably the hypothalamus. Ca++ and Mg++, known neurodepressants, probably exert their action by decreasing metabolism and neuroconductivity of inhibitory nerve fibers acting on the lateral hypothalamus. Preinjections with the neurostimulants Na+ or K+ would tend to neutralize such changes in neuroexcitability, so that the combination of ions would result in a net no effect, as far as feeding in concerned. Feeding and drinking behaviors were more sensitive than IP temperature to the ionic changes in the cerebrospinal fluid of sheep." @default.
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• W2024283663 date "1973-05-01" @default.
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• W2024283663 title "Ionic changes in cerebrospinal fluid and feeding, drinking and temperature of sheep" @default.
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• W2024283663 doi "https://doi.org/10.1016/0031-9384(73)90062-0" @default.
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